Nitrogen-doped carbon@TiO<sub>2</sub> double-shelled hollow spheres as an electrochemical sensor for simultaneous determination of dopamine and paracetamol in human serum and saliva

Hui Yang; Gongxun Cao; Yongjun Huang; Ye Lin; Fengying Zheng; Luxiu Lin; Fengjiao Liu; Shunxing Li

doi:10.1016/j.jpha.2021.08.005

Volume 12 Issue 3

Jun. 2022

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Article Navigation > Journal of Pharmaceutical Analysis > 2022 > 12(3): 436-445

Hui Yang, Gongxun Cao, Yongjun Huang, Ye Lin, Fengying Zheng, Luxiu Lin, Fengjiao Liu, Shunxing Li. Nitrogen-doped carbon@TiO2 double-shelled hollow spheres as an electrochemical sensor for simultaneous determination of dopamine and paracetamol in human serum and saliva[J]. Journal of Pharmaceutical Analysis, 2022, 12(3): 436-445. doi: 10.1016/j.jpha.2021.08.005

Citation:

Hui Yang, Gongxun Cao, Yongjun Huang, Ye Lin, Fengying Zheng, Luxiu Lin, Fengjiao Liu, Shunxing Li. Nitrogen-doped carbon@TiO₂ double-shelled hollow spheres as an electrochemical sensor for simultaneous determination of dopamine and paracetamol in human serum and saliva[J]. Journal of Pharmaceutical Analysis, 2022, 12(3): 436-445. doi: 10.1016/j.jpha.2021.08.005

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Nitrogen-doped carbon@TiO₂ double-shelled hollow spheres as an electrochemical sensor for simultaneous determination of dopamine and paracetamol in human serum and saliva

doi: 10.1016/j.jpha.2021.08.005

a. College of Chemistry, Chemical Engineering and Environment, Minnan Normal University, Zhangzhou, Fujian, 363000, China;
b. Fujian Provincial Key Laboratory of Pollution Monitoring and Control, Minnan Normal University, Zhangzhou, Fujian, 363000, China;
c. Fujian Key Laboratory of Separation and Analysis Science and Technology, Zhangzhou, Fujian, 363000, China

Funds:

This work was supported by the National Natural Science Foundation of China (Grant Nos.: 22074058 and 21675077), the Project of Industry-University-Research Cooperation of Fujian Province (Grant No.: 2019Y4010), and the Education-Science Research Project for Young and Middle-aged Teachers of Fujian (Grant No.: JAT200317).

Received Date: Nov. 04, 2020
Accepted Date: Aug. 30, 2021
Rev Recd Date: Aug. 21, 2021
Publish Date: Sep. 01, 2021

Abstract

Abstract

As the most commonly used antipyretic and analgesic drug, paracetamol (PA) coexists with neurotransmitter dopamine (DA) in real biological samples. Their simultaneous determination is extremely important for human health, but they also interfere with each other. In order to improve the conductivity, adsorption affinity, sensitivity, and selectivity of TiO₂-based electrochemical sensor, N-doped carbon@TiO₂ double-shelled hollow sphere (H-C/N@TiO₂) is designed and synthesized by simple alcoholic and hydrothermal method, using polystyrene sphere (PS) as a template. Meanwhile, TiO₂ hollow spheres (H-TiO₂) or N-doped carbon hollow spheres (H-C/N) are also prepared by the same method. H-C/N@TiO₂ has good conductivity, charge separation, and the highly enhanced and stable current responses for the detection of PA and DA. The detection limit and linear range are 50.0 nmol/L and 0.3-50 μmol/L for PA, 40.0 nmol/L and 0.3-50 μmol/L for DA, respectively, which are better than those of carbon-based sensors. Moreover, this electrochemical sensor, with high selectivity, strong anti-interference, high reliability, and long time durability, can be used for the simultaneous detection of PA and DA in human blood serum and saliva. The high electrochemical performance of H-C/N@TiO₂ is attributed to the multi-functional combination of different layers, because of good conductivity, absorption and electrons transfer ability from in-situ N-doped carbon and electrocatalytic activity from TiO₂.
- Electrochemical sensor,
- Simultaneous determination,
- Paracetamol,
- Dopamine

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References(51)

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