Volume 12 Issue 3
Jun.  2022
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Article Contents
Hendris Wongso. Natural product-based radiopharmaceuticals:Focus on curcumin and its analogs, flavonoids, and marine peptides[J]. Journal of Pharmaceutical Analysis, 2022, 12(3): 380-393. doi: 10.1016/j.jpha.2021.07.006
Citation: Hendris Wongso. Natural product-based radiopharmaceuticals:Focus on curcumin and its analogs, flavonoids, and marine peptides[J]. Journal of Pharmaceutical Analysis, 2022, 12(3): 380-393. doi: 10.1016/j.jpha.2021.07.006

Natural product-based radiopharmaceuticals:Focus on curcumin and its analogs, flavonoids, and marine peptides

doi: 10.1016/j.jpha.2021.07.006
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This study was supported by the Center for Applied Nuclear Science and Technology of the National Nuclear Energy Agency of Indonesia.

  • Received Date: Oct. 11, 2020
  • Accepted Date: Jul. 19, 2021
  • Rev Recd Date: May 19, 2021
  • Publish Date: Jul. 21, 2021
  • Natural products provide a bountiful supply of pharmacologically relevant precursors for the development of various drug-related molecules, including radiopharmaceuticals. However, current knowledge regarding the importance of natural products in developing new radiopharmaceuticals remains limited. To date, several radionuclides, including gallium-68, technetium-99m, fluorine-18, iodine-131, and iodine-125, have been extensively studied for the synthesis of diagnostic and therapeutic radiopharmaceuticals. The availability of various radiolabeling methods allows the incorporation of these radionuclides into bioactive molecules in a practical and efficient manner. Of the radiolabeling methods, direct radioiodination, radiometal complexation, and halogenation are generally suitable for natural products owing to their simplicity and robustness. This review highlights the pharmacological benefits of curcumin and its analogs, flavonoids, and marine peptides in treating human pathologies and provides a perspective on the potential use of these bioactive compounds as molecular templates for the design and development of new radiopharmaceuticals. Additionally, this review provides insights into the current strategies for labeling natural products with various radionuclides using either direct or indirect methods.
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