Capillary electrophoresis methods for impurity profiling of drugs: A review of the past decade

Mansi Shah; Nrupesh Patel; Nagja Tripathi; Vivek K. Vyas

doi:10.1016/j.jpha.2021.06.009

Volume 12 Issue 1

Feb. 2022

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Mansi Shah, Nrupesh Patel, Nagja Tripathi, Vivek K. Vyas. Capillary electrophoresis methods for impurity profiling of drugs: A review of the past decade[J]. Journal of Pharmaceutical Analysis, 2022, 12(1): 15-28. doi: 10.1016/j.jpha.2021.06.009

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Mansi Shah, Nrupesh Patel, Nagja Tripathi, Vivek K. Vyas. Capillary electrophoresis methods for impurity profiling of drugs: A review of the past decade[J]. Journal of Pharmaceutical Analysis, 2022, 12(1): 15-28. doi: 10.1016/j.jpha.2021.06.009

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Capillary electrophoresis methods for impurity profiling of drugs: A review of the past decade

doi: 10.1016/j.jpha.2021.06.009

a. Department of Pharmaceutical Analysis, Institute of Pharmacy, Nirma University, Ahmedabad, 382 481, Gujarat, India;
b. Department of Pharmacognosy, Institute of Pharmacy, Nirma University, Ahmedabad, 382 481, Gujarat, India;
c. Department of Pharmaceutical Chemistry, Institute of Pharmacy, Nirma University, Ahmedabad, 382 481, Gujarat, India

Funds:

The authors would like to thank Institute of Pharmacy, Nirma University, Ahmedabad, India for providing the necessary facilities.

Received Date: Aug. 27, 2020
Accepted Date: Jun. 30, 2021
Rev Recd Date: Jun. 02, 2021
Publish Date: Jul. 02, 2021

Abstract

Abstract

Capillary electrophoresis (CE) is widely used for the impurity profiling of drugs that contain stereochemical centers in their structures, analysis of biomolecules, and characterization of biopharmaceuticals. Currently, CE is the method of choice for the analysis of foodstuffs and the determination of adulterants. This article discusses the general theory and instrumentation of CE as well as the classification of various CE techniques. It also presents an overview of research on the applications of different CE techniques in the impurity profiling of drugs in the past decade. The review briefly presents a comparison between CE and liquid chromatography methods and highlights the strengths of CE using drug compounds as examples. This review will help scientists, fellow researchers, and students to understand the applications of CE techniques in the impurity profiling of drugs.
- Capillary electrophoresis,
- Impurities,
- Impurity profiling,
- Drugs

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References(77)

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