Reversible regulation of enzyme-like activity of molybdenum disulfide quantum dots for colorimetric pharmaceutical analysis

Juan Tan; Shiyue Wu; Qingqing Cai; Yi Wang; Pu Zhang

doi:10.1016/j.jpha.2021.03.010

Volume 12 Issue 1

Feb. 2022

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Article Navigation > Journal of Pharmaceutical Analysis > 2022 > 12(1): 113-121

Juan Tan, Shiyue Wu, Qingqing Cai, Yi Wang, Pu Zhang. Reversible regulation of enzyme-like activity of molybdenum disulfide quantum dots for colorimetric pharmaceutical analysis[J]. Journal of Pharmaceutical Analysis, 2022, 12(1): 113-121. doi: 10.1016/j.jpha.2021.03.010

Citation:

Juan Tan, Shiyue Wu, Qingqing Cai, Yi Wang, Pu Zhang. Reversible regulation of enzyme-like activity of molybdenum disulfide quantum dots for colorimetric pharmaceutical analysis[J]. Journal of Pharmaceutical Analysis, 2022, 12(1): 113-121. doi: 10.1016/j.jpha.2021.03.010

Citation:

Juan Tan, Shiyue Wu, Qingqing Cai, Yi Wang, Pu Zhang. Reversible regulation of enzyme-like activity of molybdenum disulfide quantum dots for colorimetric pharmaceutical analysis[J]. Journal of Pharmaceutical Analysis, 2022, 12(1): 113-121. doi: 10.1016/j.jpha.2021.03.010

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Reversible regulation of enzyme-like activity of molybdenum disulfide quantum dots for colorimetric pharmaceutical analysis

doi: 10.1016/j.jpha.2021.03.010

Juan Tan^a,
Shiyue Wu^a,
Qingqing Cai^a,
Yi Wang^{a
,
,},
Pu Zhang^{b
,
,}

a. Engineering Research Center for Biotechnology of Active Substances, Ministry of Education, Chongqing Key Laboratory of Green Synthesis and Applications, College of Chemistry, Chongqing Normal University, Chongqing, 401331, China;
b. Chongqing Research Center for Pharmaceutical Engineering, College of Pharmacy, Chongqing Medical University, Chongqing, 400016, China

Funds:

This work was supported by the National Natural Science Foundation of China (Grant Nos.: 21775014 and 81972020) and Open Foundation Project of Engineering Research Center for Biotechnology of Active Substances, Ministry of Education (Grant No.: AS201905). Pu Zhang and Yi Wang were sponsored by the Chongqing Talent Program (Top-notch Youth) and the Chongqing High-level Personnel of Special Support Program (Top-notch Youth), respectively.

Received Date: Sep. 09, 2020
Accepted Date: Mar. 25, 2021
Rev Recd Date: Feb. 24, 2021
Publish Date: Mar. 31, 2021

Abstract

Abstract

Regulating the catalytic activity of nanozymes is significant for their applications in various fields. Here, we demonstrate a new strategy to achieve reversible regulation of the nanozyme's activity for sensing purpose. This strategy involves the use of zero-dimensional MoS₂ quantum dots (MQDs) as the building blocks of nanozymes which display very weak peroxidase (POD)-like activity. Interestingly, such POD-like activity of the MQDs largely enhances in the presence of Fe³⁺ while diminishes with the addition of captopril thereafter. Further investigations identify the mechanism of Fe³⁺-mediated aggregation-induced enhancement of the POD-like activity and the inhibitory effect of captopril on the enhancement, which is highly dependent on their concentrations. Based on this finding, a colorimetric method for the detection of captopril is developed. This sensing approach exhibits the merits of simplicity, rapidness, reliability, and low cost, which has been successfully applied in quality control of captopril in pharmaceutical products. Moreover, the present sensing platform allows smartphone read-out, which has promising applications in point-of-care testing devices for clinical diagnosis and drug analysis.
- Nanozyme,
- Aggregation,
- Peroxidase,
- Captopril,
- Colorimetric detection,
- Smartphone

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References(58)

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