Screening strategies for quorum sensing inhibitors in combating bacterial infections

Lan Lu; Mingxing Li; Guojuan Yi; Li Liao; Qiang Cheng; Jie Zhu; Bin Zhang; Yingying Wang; Yong Chen; Ming Zeng

doi:10.1016/j.jpha.2021.03.009

Volume 12 Issue 1

Feb. 2022

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Lan Lu, Mingxing Li, Guojuan Yi, Li Liao, Qiang Cheng, Jie Zhu, Bin Zhang, Yingying Wang, Yong Chen, Ming Zeng. Screening strategies for quorum sensing inhibitors in combating bacterial infections[J]. Journal of Pharmaceutical Analysis, 2022, 12(1): 1-14. doi: 10.1016/j.jpha.2021.03.009

Citation:

Lan Lu, Mingxing Li, Guojuan Yi, Li Liao, Qiang Cheng, Jie Zhu, Bin Zhang, Yingying Wang, Yong Chen, Ming Zeng. Screening strategies for quorum sensing inhibitors in combating bacterial infections[J]. Journal of Pharmaceutical Analysis, 2022, 12(1): 1-14. doi: 10.1016/j.jpha.2021.03.009

Citation:

Lan Lu, Mingxing Li, Guojuan Yi, Li Liao, Qiang Cheng, Jie Zhu, Bin Zhang, Yingying Wang, Yong Chen, Ming Zeng. Screening strategies for quorum sensing inhibitors in combating bacterial infections[J]. Journal of Pharmaceutical Analysis, 2022, 12(1): 1-14. doi: 10.1016/j.jpha.2021.03.009

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Screening strategies for quorum sensing inhibitors in combating bacterial infections

doi: 10.1016/j.jpha.2021.03.009

a. Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengdu, 610000, China;
b. Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China

Funds:

This study was funded by the National Natural Science Foundation of China (Grant No.: 81803812).

Received Date: Aug. 12, 2020
Accepted Date: Mar. 25, 2021
Rev Recd Date: Mar. 04, 2021
Publish Date: Apr. 02, 2021

Abstract

Abstract

Interference with quorum sensing (QS) represents an antivirulence strategy with a significant promise for the treatment of bacterial infections and a new approach to restoring antibiotic tolerance. Over the past two decades, a novel series of studies have reported that quorum quenching approaches and the discovery of quorum sensing inhibitors (QSIs) have a strong impact on the discovery of anti-infective drugs against various types of bacteria. The discovery of QSI was demonstrated to be an appropriate strategy to expand the anti-infective therapeutic approaches to complement classical antibiotics and antimicrobial agents. For the discovery of QSIs, diverse approaches exist and develop in-step with the scale of screening as well as specific QS systems. This review highlights the latest findings in strategies and methodologies for QSI screening, involving activity-based screening with bioassays, chemical methods to seek bacterial QS pathways for QSI discovery, virtual screening for QSI screening, and other potential tools for interpreting QS signaling, which are innovative routes for future efforts to discover additional QSIs to combat bacterial infections.
- Quorum sensing inhibitor,
- Quorum quenching,
- Anti-infective agent,
- Screening strategies

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References(122)

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