Volume 11 Issue 3
Jun.  2021
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Article Navigation >  Journal of Pharmaceutical Analysis  > 2021  >  11(3): 257-264
Congshan Jiang, Xiaowei Li, Changrong Ge, Yuanyuan Ding, Tao Zhang, Shuai Cao, Liesu Meng, Shemin Lu. Molecular detection of SARS-CoV-2 being challenged by virus variation and asymptomatic infection[J]. Journal of Pharmaceutical Analysis, 2021, 11(3): 257-264. doi: 10.1016/j.jpha.2021.03.006
Citation: Congshan Jiang, Xiaowei Li, Changrong Ge, Yuanyuan Ding, Tao Zhang, Shuai Cao, Liesu Meng, Shemin Lu. Molecular detection of SARS-CoV-2 being challenged by virus variation and asymptomatic infection[J]. Journal of Pharmaceutical Analysis, 2021, 11(3): 257-264. doi: 10.1016/j.jpha.2021.03.006
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Molecular detection of SARS-CoV-2 being challenged by virus variation and asymptomatic infection

doi: 10.1016/j.jpha.2021.03.006

  • a. Institute of Molecular and Translational Medicine (IMTM); Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, 76 West Yanta Road, Xi’an, Shaanxi, 710061, PR China;

  • b. Key Laboratory of Environment and Genes Related to Diseases (Xi’an Jiaotong University), Ministry of Education, Xi’an, Shaanxi, 710061, PR China;

  • c. Section for Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, 17177, Sweden;

  • d. School of Pharmacy, Xi’an Jiaotong University Health Science Center, 76 West Yanta Road, Xi’an, Shaanxi, 710061, PR China;

  • e. Department of Orthopedics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, 710004, PR China

Funds:

This work was supported by the National Natural Science Foundation of China (project No. 81970029), Fundamental Research Funds for the Central Universities of China (The Emergency Projects on COVID-19, xzy032020042), and Qinnong Bank-XJTU special project for COVID-19 (qnxjtu-12).

  • Received Date: Feb. 25, 2021
  • Accepted Date: Mar. 22, 2021
  • Rev Recd Date: Mar. 17, 2021
  • Available Online: Jan. 24, 2022
  • Publish Date: Jun. 15, 2021
    Abstract
  • Coronavirus disease 2019 (COVID-19) has been a pandemic for more than a year. With the expanding second wave of the pandemic in winter, the continuous evolution of SARS-CoV-2 has brought new issues, including the significance of virus mutations in infection and the detection of asymptomatic infection. In this review, we first introduced several major SARS-CoV-2 mutations since the COVID-19 outbreak and then mentioned the widely used molecular detection techniques to diagnose COVID-19, primarily focusing on their strengths and limitations. We further discussed the effects of viral genetic variation and asymptomatic infection on the molecular detection of SARS-CoV-2 infection. The review finally summarized useful insights into the molecular diagnosis of COVID-19 under the special situation being challenged by virus mutation and asymptomatic infection.
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