Long-chain alkanol–alkyl carboxylic acid-based low-viscosity hydrophobic deep eutectic solvents for one-pot extraction of anthraquinones from Rhei Radix et Rhizoma

Anqi Huang; Wenwen Deng; Xiao Li; Qutong Zheng; Xuanxuan Wang; Yuxiu Xiao

doi:10.1016/j.jpha.2021.03.002

Volume 12 Issue 1

Feb. 2022

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Article Navigation > Journal of Pharmaceutical Analysis > 2022 > 12(1): 87-95

Anqi Huang, Wenwen Deng, Xiao Li, Qutong Zheng, Xuanxuan Wang, Yuxiu Xiao. Long-chain alkanol–alkyl carboxylic acid-based low-viscosity hydrophobic deep eutectic solvents for one-pot extraction of anthraquinones from Rhei Radix et Rhizoma[J]. Journal of Pharmaceutical Analysis, 2022, 12(1): 87-95. doi: 10.1016/j.jpha.2021.03.002

Citation:

Anqi Huang, Wenwen Deng, Xiao Li, Qutong Zheng, Xuanxuan Wang, Yuxiu Xiao. Long-chain alkanol–alkyl carboxylic acid-based low-viscosity hydrophobic deep eutectic solvents for one-pot extraction of anthraquinones from Rhei Radix et Rhizoma[J]. Journal of Pharmaceutical Analysis, 2022, 12(1): 87-95. doi: 10.1016/j.jpha.2021.03.002

Citation:

Anqi Huang, Wenwen Deng, Xiao Li, Qutong Zheng, Xuanxuan Wang, Yuxiu Xiao. Long-chain alkanol–alkyl carboxylic acid-based low-viscosity hydrophobic deep eutectic solvents for one-pot extraction of anthraquinones from Rhei Radix et Rhizoma[J]. Journal of Pharmaceutical Analysis, 2022, 12(1): 87-95. doi: 10.1016/j.jpha.2021.03.002

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Long-chain alkanol–alkyl carboxylic acid-based low-viscosity hydrophobic deep eutectic solvents for one-pot extraction of anthraquinones from Rhei Radix et Rhizoma

doi: 10.1016/j.jpha.2021.03.002

a. Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Ministry of Education); Wuhan University School of Pharmaceutical Sciences, Wuhan, 430071, China;
b. National 111 Center for Cellular Regulation and Molecular Pharmaceutics; School of Bioengineering and Food Science, Hubei University of Technology, Wuhan, Hubei, 430068, China

Funds:

We thank the National Natural Science Foundation of China (Grant Nos.: 81673394 and 82073811), the Fundamental Research Funds for the Central Universities (Grant No.: 2042020kf1010), and the Large-scale Instrument and Equipment Sharing Foundation of Wuhan University (Grant No.: LF20170838).

Received Date: Sep. 03, 2020
Accepted Date: Mar. 08, 2021
Rev Recd Date: Jan. 01, 2021
Publish Date: Mar. 17, 2021

Abstract

Abstract

Natural long-chain alkanol and alkyl carboxylic acid were used to prepare novel hydrophobic deep eutectic solvents (HDESs). These HDESs are liquid at room temperature and have low viscosity (<12.26 mPa‧s), low polarity (lower than that of methanol, ChCl-based deep eutectic solvents and other reported HDESs), and low density (<0.928 g/mL). A simple one-pot method based on a novel HDES–water two-phase extraction system was constructed for the extraction of weak-polarity bioactive components, anthraquinones, from Rhei Radix et Rhizoma. This HDES-based new extraction method does not consume hazardous organic solvents and can obtain a total anthraquinone yield of 21.52 mg/g, which is close to that obtained by the Chinese pharmacopoeia method (21.22 mg/g) and considerably higher than those by other reported HDESs-based extraction methods (14.20–20.09 mg/g, p < 0.01). The high extraction yield can be mainly attributed to the severe destruction of the RRR cell walls by the extraction system and the excellent dissolving ability of novel HDESs for anthraquinones.
- Hydrophobic deep eutectic solvent,
- Long-chain alkanol,
- Long-chain alkyl carboxylic acid,
- One-pot extraction,
- Anthraquinone

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References(47)

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