Jiagen Li, Xinming Li, Pengwei Xie, Peng Liu. Regulation of drug release performance using mixed doxorubicin-doxorubicin dimer nanoparticles as a pH-triggered drug self-delivery system[J]. Journal of Pharmaceutical Analysis, 2022, 12(1): 122-128. doi: 10.1016/j.jpha.2021.03.001
Citation: Jiagen Li, Xinming Li, Pengwei Xie, Peng Liu. Regulation of drug release performance using mixed doxorubicin-doxorubicin dimer nanoparticles as a pH-triggered drug self-delivery system[J]. Journal of Pharmaceutical Analysis, 2022, 12(1): 122-128. doi: 10.1016/j.jpha.2021.03.001

Regulation of drug release performance using mixed doxorubicin-doxorubicin dimer nanoparticles as a pH-triggered drug self-delivery system

doi: 10.1016/j.jpha.2021.03.001
  • Received Date: Aug. 03, 2020
  • Accepted Date: Mar. 05, 2021
  • Rev Recd Date: Feb. 25, 2021
  • Publish Date: Mar. 09, 2021
  • A mixed drug self-delivery system (DSDS) with high drug content (>50%) was developed to regulate pH-triggered drug release, based on two doxorubicin (DOX)-DOX dimmers: D-DOXADH and D-DOXcar conjugated with acid-labile dynamic covalent bonds (hydrazone and carbamate, respectively) and stabilized with PEGylated D-DOXADH (D-DOXADH-PEG). Owing to the different stability of the dynamic covalent bonds in the two dimers and the noncovalent interaction between them, pH-triggered drug release could be easily regulated by adjusting the feeding ratios of the two DOX-DOX dimers in the mixed DSDS. Similar in vitro cellular toxicity was achieved with the mixed DSDS nanoparticles prepared with different feeding ratios. The mixed DSDS nanoparticles had a similar DOX content and diameter but different drug releasing rates. The MTT assays revealed that a high anti-tumor efficacy could be achieved with the slow-release mixed DSDS nanoparticles.
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