Regulation of drug release performance using mixed doxorubicin-doxorubicin dimer nanoparticles as a pH-triggered drug self-delivery system

Jiagen Li; Xinming Li; Pengwei Xie; Peng Liu

doi:10.1016/j.jpha.2021.03.001

Volume 12 Issue 1

Feb. 2022

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Jiagen Li, Xinming Li, Pengwei Xie, Peng Liu. Regulation of drug release performance using mixed doxorubicin-doxorubicin dimer nanoparticles as a pH-triggered drug self-delivery system[J]. Journal of Pharmaceutical Analysis, 2022, 12(1): 122-128. doi: 10.1016/j.jpha.2021.03.001

Citation:

Jiagen Li, Xinming Li, Pengwei Xie, Peng Liu. Regulation of drug release performance using mixed doxorubicin-doxorubicin dimer nanoparticles as a pH-triggered drug self-delivery system[J]. Journal of Pharmaceutical Analysis, 2022, 12(1): 122-128. doi: 10.1016/j.jpha.2021.03.001

Citation:

Jiagen Li, Xinming Li, Pengwei Xie, Peng Liu. Regulation of drug release performance using mixed doxorubicin-doxorubicin dimer nanoparticles as a pH-triggered drug self-delivery system[J]. Journal of Pharmaceutical Analysis, 2022, 12(1): 122-128. doi: 10.1016/j.jpha.2021.03.001

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Regulation of drug release performance using mixed doxorubicin-doxorubicin dimer nanoparticles as a pH-triggered drug self-delivery system

doi: 10.1016/j.jpha.2021.03.001

State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, China

Received Date: Aug. 03, 2020
Accepted Date: Mar. 05, 2021
Rev Recd Date: Feb. 25, 2021
Publish Date: Mar. 09, 2021

Abstract

Abstract

A mixed drug self-delivery system (DSDS) with high drug content (>50%) was developed to regulate pH-triggered drug release, based on two doxorubicin (DOX)-DOX dimmers: D-DOX_ADH and D-DOX_car conjugated with acid-labile dynamic covalent bonds (hydrazone and carbamate, respectively) and stabilized with PEGylated D-DOX_ADH (D-DOX_ADH-PEG). Owing to the different stability of the dynamic covalent bonds in the two dimers and the noncovalent interaction between them, pH-triggered drug release could be easily regulated by adjusting the feeding ratios of the two DOX-DOX dimers in the mixed DSDS. Similar in vitro cellular toxicity was achieved with the mixed DSDS nanoparticles prepared with different feeding ratios. The mixed DSDS nanoparticles had a similar DOX content and diameter but different drug releasing rates. The MTT assays revealed that a high anti-tumor efficacy could be achieved with the slow-release mixed DSDS nanoparticles.
- Drug self-delivery system,
- Regulated drug release,
- Doxorubicin-doxorubicin dimer,
- Acid-triggered release,
- Mixed nanoparticles

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References(21)

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