Fabrication of edge-curled petals-like covalent organic frameworks and their properties for extracting indole alkaloids from complex biological samples

Fanrong Sun; Ligai Bai; Mingxue Li; Changqing Yu; Haiyan Liu; Xiaoqiang Qiao; Hongyuan Yan

doi:10.1016/j.jpha.2020.12.006

Volume 12 Issue 1

Feb. 2022

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Article Navigation > Journal of Pharmaceutical Analysis > 2022 > 12(1): 96-103

Fanrong Sun, Ligai Bai, Mingxue Li, Changqing Yu, Haiyan Liu, Xiaoqiang Qiao, Hongyuan Yan. Fabrication of edge-curled petals-like covalent organic frameworks and their properties for extracting indole alkaloids from complex biological samples[J]. Journal of Pharmaceutical Analysis, 2022, 12(1): 96-103. doi: 10.1016/j.jpha.2020.12.006

Citation:

Fanrong Sun, Ligai Bai, Mingxue Li, Changqing Yu, Haiyan Liu, Xiaoqiang Qiao, Hongyuan Yan. Fabrication of edge-curled petals-like covalent organic frameworks and their properties for extracting indole alkaloids from complex biological samples[J]. Journal of Pharmaceutical Analysis, 2022, 12(1): 96-103. doi: 10.1016/j.jpha.2020.12.006

Citation:

Fanrong Sun, Ligai Bai, Mingxue Li, Changqing Yu, Haiyan Liu, Xiaoqiang Qiao, Hongyuan Yan. Fabrication of edge-curled petals-like covalent organic frameworks and their properties for extracting indole alkaloids from complex biological samples[J]. Journal of Pharmaceutical Analysis, 2022, 12(1): 96-103. doi: 10.1016/j.jpha.2020.12.006

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Fabrication of edge-curled petals-like covalent organic frameworks and their properties for extracting indole alkaloids from complex biological samples

doi: 10.1016/j.jpha.2020.12.006

Fanrong Sun^a,b,
Ligai Bai^{a,b,c
,
,},
Mingxue Li^a,b,
Changqing Yu^a,b,
Haiyan Liu^a,b,c,
Xiaoqiang Qiao^a,b,c,
Hongyuan Yan^{a,b,c
,
,}

a. College of Pharmaceutical Sciences, Hebei University, Baoding, 071002, Hebei, China;
b. Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Baoding, 071002, Hebei, China;
c. Institute of Life Science and Green Development, Hebei University, Baoding, 071002, Hebei, China

Funds:

This work was supported by the Natural Science Foundation of Hebei Province (Grant No.: B2020201002), the National Natural Science Foundation of China (Grant Nos.: 21974034 and 21505030), and the Interdisciplinary Research Project of Natural Science of Hebei University (Grant No.: DXK201912).

Received Date: Jun. 12, 2020
Accepted Date: Dec. 20, 2020
Rev Recd Date: Sep. 17, 2020
Publish Date: Dec. 24, 2020

Abstract

Abstract

In this study, a functionalized covalent-organic framework (COF) was first synthesized using porphyrin as the fabrication unit and showed an edge-curled, petal-like and well-ordered structure. The synthesized COF was then introduced to prepare porous organic polymer monolithic materials (POPMs). Two composite POPM/COF monolithic materials with rod shapes, referred to as sorbent A and sorbent B, were prepared in stainless steel tubes using different monomers. Sorbents A and B exhibited relatively uniform porous structures and enhanced specific surface areas of 153.14 m²/g and 80.01 m²/g, respectively. The prepared composite monoliths were used as in-tube solid-phase extraction (SPE) sorbents combined with HPLC for the on-line extraction and quantitative analytical systems. Indole alkaloids (from Catharanthus roseus G. Don and Uncaria rhynchophylla (Miq.) Miq. Ex Havil.) contained in mouse plasma were extracted and quantitatively analyzed using the online system. The two composite multifunctional monoliths showed excellent clean-up ability for complex biological matrices, as well as superior selectivity for target indole alkaloids. Method validation showed that the RSD values of the repeatability (n=6) were ≤ 3.46%, and the accuracy expressed by the spiked recoveries was in the ranges of 99.38%–100.91% and 96.39%–103.50% for vinca alkaloids and Uncaria alkaloids, respectively. Furthermore, sorbents A and B exhibited strong reusability, with RSD values ≤ 5.32%, which were based on the peak area of the corresponding alkaloids with more than 100 injections. These results indicate that the composite POPM/COF rod-shaped monoliths are promising media as SPE sorbents for extracting trace compounds in complex biological samples.
- Covalent organic frameworks,
- Monolithic material,
- Solid-phase extraction,
- Alkaloids,
- Biological samples

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References(48)

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