Volume 11 Issue 2
Apr.  2021
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Wafaa Boumya, Nawal Taoufik, Mounia Achak, Noureddine Barka. Chemically modified carbon-based electrodes for the determination of paracetamol in drugs and biological samples[J]. Journal of Pharmaceutical Analysis, 2021, 11(2): 138-154. doi: 10.1016/j.jpha.2020.11.003
Citation: Wafaa Boumya, Nawal Taoufik, Mounia Achak, Noureddine Barka. Chemically modified carbon-based electrodes for the determination of paracetamol in drugs and biological samples[J]. Journal of Pharmaceutical Analysis, 2021, 11(2): 138-154. doi: 10.1016/j.jpha.2020.11.003

Chemically modified carbon-based electrodes for the determination of paracetamol in drugs and biological samples

doi: 10.1016/j.jpha.2020.11.003
  • Received Date: May 04, 2020
  • Accepted Date: Nov. 05, 2020
  • Rev Recd Date: Oct. 26, 2020
  • Publish Date: Nov. 09, 2020
  • Paracetamol is a non-steroidal, anti-inflammatory drug widely used in pharmaceutical applications for its sturdy, antipyretic and analgesic action. However, an overdose of paracetamol can cause fulminant hepatic necrosis and other toxic effects. Thus, the development of advantageous analytical tools to detect and determine paracetamol is required. Due to simplicity, higher sensitivity and selectivity as well as costefficiency, electrochemical sensors were fully investigated in last decades. This review describes the advancements made in the development of electrochemical sensors for the paracetamol detection and quantification in pharmaceutical and biological samples. The progress made in electrochemical sensors for the selective detection of paracetamol in the last 10 years was examined, with a special focus on highly innovative features introduced by nanotechnology. As the literature is rather extensive, we tried to simplify this work by summarizing and grouping electrochemical sensors according to the by which manner their substrates were chemically modified and the analytical performances obtained.
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