Determination of bisphosphonates anti-resorptive properties based on three forms of ceramic materials: Sorption and release process evaluation

Monika Zielińska; Ewa Chmielewska; Tomasz Buchwald; Adam Voelkel; Paweł Kafarski

doi:10.1016/j.jpha.2020.07.011

Volume 11 Issue 3

Jun. 2021

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Monika Zielińska, Ewa Chmielewska, Tomasz Buchwald, Adam Voelkel, Paweł Kafarski. Determination of bisphosphonates anti-resorptive properties based on three forms of ceramic materials: Sorption and release process evaluation[J]. Journal of Pharmaceutical Analysis, 2021, 11(3): 364-373. doi: 10.1016/j.jpha.2020.07.011

Citation:

Monika Zielińska, Ewa Chmielewska, Tomasz Buchwald, Adam Voelkel, Paweł Kafarski. Determination of bisphosphonates anti-resorptive properties based on three forms of ceramic materials: Sorption and release process evaluation[J]. Journal of Pharmaceutical Analysis, 2021, 11(3): 364-373. doi: 10.1016/j.jpha.2020.07.011

Citation:

Monika Zielińska, Ewa Chmielewska, Tomasz Buchwald, Adam Voelkel, Paweł Kafarski. Determination of bisphosphonates anti-resorptive properties based on three forms of ceramic materials: Sorption and release process evaluation[J]. Journal of Pharmaceutical Analysis, 2021, 11(3): 364-373. doi: 10.1016/j.jpha.2020.07.011

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Determination of bisphosphonates anti-resorptive properties based on three forms of ceramic materials: Sorption and release process evaluation

doi: 10.1016/j.jpha.2020.07.011

a. Poznań University of Technology, Institute of Chemical Technology and Engineering, Ul. Berdychowo 4, 60-965, Poznań, Poland;
b. Wrocław University of Science and Technology, Faculty of Chemistry, Department of Bioorganic Chemistry, Wybrzeże Wyspiańskiego 27, 50-370, Wrocław, Poland;
c. Poznań University of Technology, Institute of Materials Research and Quantum Engineering, Piotrowo 3, 60-965, Poznan, Poland

Funds:

This work was supported by the Ministry of Science and Higher Education grants and subsidy of the Ministry of Science and Higher Education.

Received Date: Apr. 15, 2020
Accepted Date: Jul. 31, 2020
Rev Recd Date: Jul. 31, 2020
Available Online: Jan. 24, 2022
Publish Date: Jun. 15, 2021

Abstract

Abstract

There is a strong need to search for more effective compounds with bone anti-resorptive properties, which will cause fewer complications than commonly used bisphosphonates. To achieve this goal, it is necessary to search for new techniques to characterize the interactions between bone and drug. By studying their interaction with hydroxyapatite (HA), this study used three forms of ceramic materials, two of which are bone-stimulating materials, to assess the suitability of new active substances with anti-resorptive properties. In this study, three methods based on HA in loose form, polycaprolactone/HA (a polymer-ceramic materials containing HA), and polymer-ceramic monolithic in-needle extraction (MINE) device (a polymer inert skeleton), respectively, were used. The affinity of risedronate (a standard compound) and sixteen aminomethylenebisphosphonates (new compounds with potential antiresorptive properties) to HA was defined according to the above-mentioned methods. Ten monolithic materials based on 2-hydroxyethyl methacrylate/ethylene dimethacrylate are prepared and studied, of which one was selected for more-detailed further research. Simulated body fluids containing bisphosphonates were passed through the MINE device. In this way, sorption–desorption of bisphosphonates was evaluated using this MINE device. The paper presents the advantages and disadvantages of each technique and its suitability for assessing new active substances. All three methods allow for the selection of several compounds with potentially higher anti-resorptive properties than risedronate, in hope that it reflects their higher bone affinity and release ability.
- Monolithic column,
- Polymer composites,
- Bisphosphonates,
- Hydroxyapatite coatings,
- Hydroxyapatite composite

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References(29)

References

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