Herb-drug interaction in the protective effect of <i>Alpinia officinarum</i> against gastric injury induced by indomethacin based on pharmacokinetic, tissue distribution and excretion studies in rats

Xuguang Zhang; Zhenrui Xie; Xun Chen; Junqiang Qiu; Yinfeng Tan; Xiaoliang Li; Hailong Li; Junqing Zhang

doi:10.1016/j.jpha.2020.05.009

Volume 11 Issue 2

Apr. 2021

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Article Navigation > Journal of Pharmaceutical Analysis > 2021 > 11(2): 200-209

Xuguang Zhang, Zhenrui Xie, Xun Chen, Junqiang Qiu, Yinfeng Tan, Xiaoliang Li, Hailong Li, Junqing Zhang. Herb-drug interaction in the protective effect of Alpinia officinarum against gastric injury induced by indomethacin based on pharmacokinetic, tissue distribution and excretion studies in rats[J]. Journal of Pharmaceutical Analysis, 2021, 11(2): 200-209. doi: 10.1016/j.jpha.2020.05.009

Citation:

Xuguang Zhang, Zhenrui Xie, Xun Chen, Junqiang Qiu, Yinfeng Tan, Xiaoliang Li, Hailong Li, Junqing Zhang. Herb-drug interaction in the protective effect of Alpinia officinarum against gastric injury induced by indomethacin based on pharmacokinetic, tissue distribution and excretion studies in rats[J]. Journal of Pharmaceutical Analysis, 2021, 11(2): 200-209. doi: 10.1016/j.jpha.2020.05.009

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Herb-drug interaction in the protective effect of Alpinia officinarum against gastric injury induced by indomethacin based on pharmacokinetic, tissue distribution and excretion studies in rats

doi: 10.1016/j.jpha.2020.05.009

Key Laboratory of Tropical Translation Medicine of Ministry of Education; Hainan Provincial Key Laboratory for Research and Development of Tropical Herbs; School of Pharmacy, Hainan Medical University, Haikou, 571199, China

Funds:

This work was financially supported by the National Natural Science Foundation of China (No. 81560721).

Received Date: Nov. 25, 2019
Accepted Date: May 22, 2020
Rev Recd Date: May 07, 2020
Publish Date: Jun. 06, 2020

Abstract

Abstract

Alpinia officinarum Hance of the Chinese traditional herb for the treatment of emesis, abdominal pain and diarrhea has been used to counteract gastric disease induced by indomethacin in rats without obvious side effects. However, the role of herb-drug interaction between indomethacin and A. officinarum based on pharmacokinetic, tissue distribution and excretion still remains unknown. In this study, an ultra-fast liquid-tandem mass spectrometry (UFLC-MS/MS) method was developed for simultaneous determination of indomethacin and its three metabolites, O-desmethylindomethacin (ODI), deschlorobenzoylindomethacin (NDI) and indomethacin acyl-β-D-glucuronide (IDAβG) by oral administration of indomethacin solution with and without the ethanolic extract of A. officinarum and applied to comparative pharmacokinetic, tissue distribution and excretion studies. Our results clarified that oral administration of A. officinarum produced significant alterations in the pharmacokinetic parameters of indomethacin. And the pharmacokinetic interaction between indomethacin and A. officinarum reduced the systemic exposure of indomethacin and increased its elimination. Tissue distribution results demonstrated that co-administration of A. Officinarum could not reduce the accumulation of indomethacin in the target tissue of the stomach, but could accelerate the excretions of indomethacin and its three metabolites including ODI, NDI and IDAβG in the bile and feces of rats in the excretion study. Therefore, A. Officinarum might have a gastrointestinal protective effect through the interaction role with indomethacin based on the pharmacokinetics and excretion in rats.
- Alpinia officinarum Hance,
- Indomethacin,
- Herb-drug interaction,
- Pharmacokinetics,
- Tissue distribution,
- Excretion

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References(30)

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