Vancomycin pretreatment attenuates acetaminophen-induced liver injury through 2-hydroxybutyric acid

Ningning Zheng; Yu Gu; Ying Hong; Lili Sheng; Linlin Chen; Feng Zhang; Jie Hou; Weidong Zhang; Zean Zhang; Wei Jia; Houkai Li

doi:10.1016/j.jpha.2019.11.003

Volume 10 Issue 6

Dec. 2020

Turn off MathJax

Article Contents

Article Navigation > Journal of Pharmaceutical Analysis > 2020 > 10(6): 560-570

Ningning Zheng, Yu Gu, Ying Hong, Lili Sheng, Linlin Chen, Feng Zhang, Jie Hou, Weidong Zhang, Zean Zhang, Wei Jia, Houkai Li. Vancomycin pretreatment attenuates acetaminophen-induced liver injury through 2-hydroxybutyric acid[J]. Journal of Pharmaceutical Analysis, 2020, 10(6): 560-570. doi: 10.1016/j.jpha.2019.11.003

Citation:

Ningning Zheng, Yu Gu, Ying Hong, Lili Sheng, Linlin Chen, Feng Zhang, Jie Hou, Weidong Zhang, Zean Zhang, Wei Jia, Houkai Li. Vancomycin pretreatment attenuates acetaminophen-induced liver injury through 2-hydroxybutyric acid[J]. Journal of Pharmaceutical Analysis, 2020, 10(6): 560-570. doi: 10.1016/j.jpha.2019.11.003

Citation:

Ningning Zheng, Yu Gu, Ying Hong, Lili Sheng, Linlin Chen, Feng Zhang, Jie Hou, Weidong Zhang, Zean Zhang, Wei Jia, Houkai Li. Vancomycin pretreatment attenuates acetaminophen-induced liver injury through 2-hydroxybutyric acid[J]. Journal of Pharmaceutical Analysis, 2020, 10(6): 560-570. doi: 10.1016/j.jpha.2019.11.003

PDF( 2526 KB)

Vancomycin pretreatment attenuates acetaminophen-induced liver injury through 2-hydroxybutyric acid

doi: 10.1016/j.jpha.2019.11.003

a. Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China;
b. College of Basic Medical Sciences, Dalian Medical University, Dalian, 116044, China;
c. School of Pharmacy, Second Military Medical University, Shanghai, 200433, China;
d. Center for Drug Safety Evaluation and Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China;
e. University of Hawaii Cancer Center, Honolulu, HI, 96813, USA;
f. Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, 200233, China

Funds:

81673662), the National Key Research and Development Program of China (No. 2017YFC1700200), Shuguang Scholar (16SG36) at Shanghai Institutions of Higher Learning from Shanghai Municipal Education Commission.

This work was funded by the National Natural Science Foundation of China (No. 81873059 &

Received Date: Jul. 09, 2019
Accepted Date: Nov. 05, 2019
Rev Recd Date: Oct. 11, 2019
Available Online: Jan. 24, 2022
Publish Date: Dec. 10, 2020

Abstract

Abstract

Liver injury caused by acetaminophen (AP) overdose is a leading public health problem. Although AP-induced liver injury is well recognized as the formation of N-acetyl-p-benzoquinone (NAPQI), a toxic metabolite of AP, resulting in cell damage, emerging evidence indicates that AP-induced liver injury is also associated with gut microbiota. However, the gut microbiota-involved mechanism remains largely unknown. In our study, we found that vancomycin (Vac) pretreatment (100 mg/kg, twice a day for 4 days) attenuated AP-induced liver injury, altered the composition of gut microbiota, and changed serum metabolic profile. Moreover, we identified Vac pretreatment elevated cecum and serum 2-hydroxybutyric acid (2-HB), which ameliorated AP-induced cell damage and liver injury in mice by reducing AP bioavailability and elevating GSH levels. Our current results revealed the novel role of 2-HB in protecting AP-induced liver injury and add new evidence for gut microbiota in affecting AP toxicity.
- revealed,
- Liver injury,
- Gut microbiota,
- Acetaminophen,
- Vancomycin,
- 2-Hydroxybutyric acid

FullText(HTML)

References(34)

References

G. Ostapowicz, R. J. Fontana, F. V. Schiodt, et al, Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. Ann. Intern. Med. 137(2002) 947-954

W. Bernal, G. Auzinger, A. Dhawan, et al, Acute liver failure. Lancet. 376(2010) 190-201

L. F. Prescott, Kinetics and metabolism of paracetamol and phenacetin. Br. J. Clin. Pharmacol. 10 Suppl 2(1980) 291S-298S

C. K. Gelotte, J. F. Auiler, J. M. Lynch, et al, Disposition of acetaminophen at 4, 6, and 8 g/day for 3 days in healthy young adults. Clin. Pharmacol. Ther. 81(2007) 840-848

J. R. Mitchell, D. J. Jollow, W. Z. Potter, et al, Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione. J. Pharmacol. Exp. Ther. 187(1973) 211-217

H. J. Haiser, P. J. Turnbaugh, Developing a metagenomic view of xenobiotic metabolism. Pharmacol. Res. 69(2013) 21-31

T. A. Clayton, D. Baker, J. C. Lindon, et al, Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism. Proc. Natl. Acad. Sci. U S A. 106(2009) 14728-14733

S. H. Lee, J. H. An, H. J. Lee, et al, Evaluation of pharmacokinetic differences of acetaminophen in pseudo germ-free rats. Biopharm. Drug. Dispos. 33(2012) 292-303

S. Gong, T. Lan, L. Zeng, et al, Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice. J. Hepatol. 69(2018) 51-59

I. K. Yap, J. V. Li, J. Saric, et al, Metabonomic and microbiological analysis of the dynamic effect of vancomycin-induced gut microbiota modification in the mouse. J. Proteome. Res. 7(2008) 3718-3728

T. A. Clayton, J. C. Lindon, O. Cloarec, et al, Pharmaco-metabonomic phenotyping and personalized drug treatment. Nature. 440(2006) 1073-1077

X. He, N. Zheng, J. He, et al, Gut Microbiota Modulation Attenuated the Hypolipidemic Effect of Simvastatin in High-Fat/Cholesterol-Diet Fed Mice. J. Proteome. Res. 16(2017) 1900-1910

X. Zhang, Y. Zhao, M. Zhang, et al, Structural changes of gut microbiota during berberine-mediated prevention of obesity and insulin resistance in high-fat diet-fed rats. PLoS. One. 7(2012) e42529

Q. Wang, L. Jiang, J. Wang, et al, Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice. Hepatology. 49(2009) 1166-1175

Z. M. Weng, P. Wang, G. B. Ge, et al, Structure-activity relationships of flavonoids as natural inhibitors against E. coli beta-glucuronidase. Food. Chem. Toxicol. 109(2017) 975-983

J. H. Jo, S. Kim, T. W. Jeon, et al, Investigation of the Regulatory Effects of Saccharin on Cytochrome P450s in Male ICR Mice. Toxicol. Res. 33(2017) 25-30

M. G. Langille, J. Zaneveld, J. G. Caporaso, et al., Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences. Nat. Biotechnol. 31(2013) 814-821

N. Watari, M. Iwai,N. Kaneniwa, Pharmacokinetic study of the fate of acetaminophen and its conjugates in rats. J. Pharmacokinet. Biopharm. 11(1983) 245-272

C. P. Siegers, K. Rozman,C. D. Klaassen, Biliary excretion and enterohepatic circulation of paracetamol in the rat. Xenobiotica. 13(1983) 591-596

C. J. Patten, P. E. Thomas, R. L. Guy, et al, Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics. Chem. Res. Toxicol. 6(1993) 511-518

K. E. Thummel, C. A. Lee, K. L. Kunze, et al, Oxidation of acetaminophen to N-acetyl-p-aminobenzoquinone imine by human CYP3A4. Biochem. Pharmacol. 45(1993) 1563-1569

S. Chaillou, M. C. Champomier-Verges, M. Cornet, et al, The complete genome sequence of the meat-borne lactic acid bacterium Lactobacillus sakei 23K. Nat. Biotechnol. 23(2005) 1527-1533

M. Monot, C. Boursaux-Eude, M. Thibonnier, et al, Reannotation of the genome sequence of Clostridium difficile strain 630. J. Med. Microbiol. 60(2011) 1193-1199

V. Kapatral, I. Anderson, N. Ivanova, et al, Genome sequence and analysis of the oral bacterium Fusobacterium nucleatum strain ATCC 25586. J. Bacteriol. 184(2002) 2005-2018

J. F. Heidelberg, R. Seshadri, S. A. Haveman, et al, The genome sequence of the anaerobic, sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough. Nat. Biotechnol. 22(2004) 554-559

R. C. Moellering, Jr., Vancomycin: a 50-year reassessment. Clin. Infect. Dis. 42 Suppl 1(2006) S3-4

N. J. Pultz, U. Stiefel,C. J. Donskey, Effects of daptomycin, linezolid, and vancomycin on establishment of intestinal colonization with vancomycin-resistant enterococci and extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae in mice. Antimicrob. Agents. Chemother. 49(2005) 3513-3516

A. Zarrinpar, A. Chaix, Z. Z. Xu, et al., Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism. Nat. Commun. 9(2018) 2872

I. Hwang, Y. J. Park, Y. R. Kim, et al, Alteration of gut microbiota by vancomycin and bacitracin improves insulin resistance via glucagon-like peptide 1 in diet-induced obesity. FASEB. J. 29(2015) 2397-2411

S. Fujisaka, J. Avila-Pacheco, M. Soto, et al, Diet, Genetics, and the Gut Microbiome Drive Dynamic Changes in Plasma Metabolites. Cell. Rep. 22(2018) 3072-3086

J. K. Nicholson, J. C. Lindon,E. Holmes, ’Metabonomics’: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica. 29(1999) 1181-1189

J. K. Nicholson, J. Connelly, J. C. Lindon, et al, Metabonomics: a platform for studying drug toxicity and gene function. Nat. Rev. Drug. Discov. 1(2002) 153-161

H. Jaeschke, T. R. Knight,M. L. Bajt, The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity. Toxicol. Lett. 144(2003) 279-288

H. Jaeschke, M. R. Mcgill,A. Ramachandran, Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity. Drug. Metab. Rev. 44(2012) 88-106

Relative Articles

Supplements(0)

Cited By

Proportional views