Antimicrobial and antiproliferative prospective of kosinostatin-a secondary metabolite isolated from Streptomyces sp.

Vinayagam Rambabu; Subramaniyan Suba; Suburamaniyan Vijayakumar

doi:10.1016/j.jpha.2014.11.002

Volume 5 Issue 6

Dec. 2015

Turn off MathJax

Article Contents

Article Navigation > Journal of Pharmaceutical Analysis > 2015 > (6): 378-382

Vinayagam Rambabu, Subramaniyan Suba, Suburamaniyan Vijayakumar. Antimicrobial and antiproliferative prospective of kosinostatin-a secondary metabolite isolated from Streptomyces sp.[J]. Journal of Pharmaceutical Analysis, 2015, (6): 378-382. doi: 10.1016/j.jpha.2014.11.002

Citation:

Vinayagam Rambabu, Subramaniyan Suba, Suburamaniyan Vijayakumar. Antimicrobial and antiproliferative prospective of kosinostatin-a secondary metabolite isolated from Streptomyces sp.[J]. Journal of Pharmaceutical Analysis, 2015, (6): 378-382. doi: 10.1016/j.jpha.2014.11.002

Citation:

Vinayagam Rambabu, Subramaniyan Suba, Suburamaniyan Vijayakumar. Antimicrobial and antiproliferative prospective of kosinostatin-a secondary metabolite isolated from Streptomyces sp.[J]. Journal of Pharmaceutical Analysis, 2015, (6): 378-382. doi: 10.1016/j.jpha.2014.11.002

PDF( 1427 KB)

Antimicrobial and antiproliferative prospective of kosinostatin-a secondary metabolite isolated from Streptomyces sp.

doi: 10.1016/j.jpha.2014.11.002

P.G. and Research Department of Botany and Microbiology, A.V.V.M. Sri Pushpam Col ege Autonomous, Poondi, Thanjavur, Tamil Nadu, India
K.K Biotec Lab Service, Chennai, Tamil Nadu, India

Publish Date: Dec. 10, 2015

Abstract

Abstract

Cancer is a communal health hazard worldwide. The present investigation attempts to evaluate anti-microbial and anticancer potential of kosinostatin on mammary carcinoma cell line (MCF-7). The an-ticancer and antiproliferative activities of kosinostatin were analyzed on MCF cell line by MTT assay and cytotoxicity assays like lactate dehydrogenase (LDH) and glutathione (GSH). The secondary metabolite kosinostatin exhibited its apoptotic nature by expressing p53 protein. Collectively, the results acquired from this study promise that kosinostatin shows the potent anticancer activity.
- Kosinostatin,
- Secondary metabolite,
- Streptomyces sp.,
- Cytotoxic activity,
- MCF-7