Patrícia Severino, George G.G. de Oliveira, Humberto G. Ferraz, Eliana B. Souto, Maria H.A. Santana. Preparation of gastro-resistant pellets containing chitosan microspheres for improvement of oral didanosine bioavailability[J]. Journal of Pharmaceutical Analysis, 2012, 02(3): 188-192. doi: 10.1016/j.jpha.2012.02.005
Citation:
Patrícia Severino, George G.G. de Oliveira, Humberto G. Ferraz, Eliana B. Souto, Maria H.A. Santana. Preparation of gastro-resistant pellets containing chitosan microspheres for improvement of oral didanosine bioavailability[J]. Journal of Pharmaceutical Analysis, 2012, 02(3): 188-192. doi: 10.1016/j.jpha.2012.02.005
Patrícia Severino, George G.G. de Oliveira, Humberto G. Ferraz, Eliana B. Souto, Maria H.A. Santana. Preparation of gastro-resistant pellets containing chitosan microspheres for improvement of oral didanosine bioavailability[J]. Journal of Pharmaceutical Analysis, 2012, 02(3): 188-192. doi: 10.1016/j.jpha.2012.02.005
Citation:
Patrícia Severino, George G.G. de Oliveira, Humberto G. Ferraz, Eliana B. Souto, Maria H.A. Santana. Preparation of gastro-resistant pellets containing chitosan microspheres for improvement of oral didanosine bioavailability[J]. Journal of Pharmaceutical Analysis, 2012, 02(3): 188-192. doi: 10.1016/j.jpha.2012.02.005
Department of Biotechnological Processes, School of Engineering Chemical, University of Campinas, Campinas 13083-970, Brazil
Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of Sāo Paulo, Sāo Paulo 05508-900, Brazil
Faculty of Health Sciences, Fernando Pessoa University, Rua Carlos da Maia, 296, 4200-150 Porto, Portugal
Institute for Biotechnology and Bioengineering, Centre of Genomics and Biotechnology, University of Trás-os-Montes e Alto Douro(IBB-CGB/UTAD), 5001-801 Vila Real, Portugal
Funds:
the Funda(ca)o de Amparo a Pesquisa do Estado de S(a)o Paulo (FAPESP/Brazil)
the Conselho Nacional de Pesquisa (CNPq,Brazil)
The authors also wish to acknowledge Funda(ca)o para a Ci(e)ncia e Tecnologia do Ministério da Ci(e)ncia e Tecnologia
The purpose of this work was to introduce a new concept of coated pellets containing chitosan microspheres loaded with didadosine for oral administration,aiming at reducing the frequency of administration and improving the bioavailability by a suitable release profile.Chitosan microspheres were produced under fluidized bed,followed by extrusion and spheronization to obtain pellets with a mean diameter of about 1 mm.The pellets were then coated with Kollidon(R) VA64 and Kollicoat(R) MAE100P in water dispersion to depict a sustained release profile.Conventional hard gelatine capsules were loaded with these pellets and tested in vitro for their release profile of didadosine.Dissolution testing confirmed that chitosan microsphere pellets provides appropriate sustained release up to 2 h behavior for didanosine.
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