2018 Vol. 8, No. 6

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2018, 8(6): 封3-封4.
Abstract(92) PDF(0)
Abstract:
Development and validation of an HPLC-UV method for analysis of methylphenidate hydrochloride and loxapine succinate in an activated carbon disposal system
Pooja Bakshi, Andrew Korey, William Fowler, Ajay K. Banga
2018, 8(6): 349-356.
Abstract(138) PDF(5) [Cited by] (5)
Abstract:
Unused medications have the possibility of being abused, causing serious harm to individuals who were not prescribed the drug. The Food and Drug Administration (FDA) recommends the proper disposal of unused prescribed medications to maintain safety and prevent environmental hazards. However, many of...
LC and LC–MS/MS studies for the identification and characterization of degradation products of acebutolol
Uday Rakibe, Ravi Tiwari, Anand Mahajan, Vipul Rane, Pravin Wakte
2018, 8(6): 357-365.
Abstract(247) PDF(4) [Cited by] (19)
Abstract:
The aim of the present investigation was to demonstrate an approach involving use of liquid chromatography (LC) and liquid chromatography-mass spectrometry (LC–MS) to separate, identify and characterize very small quantities of degradation products (DPs) of acebutolol without their isolation from th...
Detection and determination of undeclared synthetic caffeine in weight loss formulations using HPLC-DAD and UHPLC-MS/MS
Carine Viana, Gabriela M. Zemolin, Thaís R. Dal Molin, Luciana Gobo, Sandra Maria Ribeiro, Gabriela C. Leal, Gabriela Z. Marcon, Leandro M. de Carvalho
2018, 8(6): 366-372.
Abstract(141) PDF(0) [Cited by] (17)
Abstract:
Caffeine is present in products marketed for weight loss, with the purpose of increasing thermogenesis and lipid metabolism. The dosage declared by the product manufacturer, or even its presence, is not always correctly described on the label. This work aimed to investigate the undeclared synthetic ...
Gas chromatography-mass spectrometry method for determination of β-propiolactone in human inactivated rabies vaccine and its hydrolysis analysis
Shuo Lei, Xun Gao, Yang Sun, Xiangyong Yu, Longshan Zhao
2018, 8(6): 373-377.
Abstract(177) PDF(0) [Cited by] (19)
Abstract:
A simple method was established for the determination of β-propiolactone (BPL) in human inactivated rabies vaccine by gas chromatography-mass spectrometry (GC-MS). The determination was performed on an Agilent HP-INNOWAX (30m × 0.32mm i.d., 0.25 μm) capillary column at the temperature of 80 °C. Elec...
Highly sensitive LC–MS/MS method to estimate doxepin and its metabolite nordoxepin in human plasma for a bioequivalence study
Nirav P. Patel, Mallika Sanyal, Naveen Sharma, Dinesh S. Patel, Pranav S. Shrivastav, Bhavin N. Patel
2018, 8(6): 378-385.
Abstract(98) PDF(0) [Cited by] (12)
Abstract:
A selective, sensitive and rugged liquid chromatography–tandem mass spectrometry (LC–MS/MS) assay has been developed for the simultaneous determination of doxepin (Dox) and its pharmacologically active metabolite, nordoxepin (NDox) in human plasma. The analytes and their internal standards (IS) were...
Long-term stability of gentamicin sulfate-ethylenediaminetetraacetic acid disodium salt (EDTA-Na2) solution for catheter locks
Anne-Sophie Fiolet, Elise Jandot, Pauline Doucey, Coralie Crétet, Célia Brunel, Christine Pivot, Jean-Marc Ghigo, Christophe Beloin, David Lebeaux, Fabrice Pirot
2018, 8(6): 386-393.
Abstract(156) PDF(5) [Cited by] (9)
Abstract:
A lock solution composed of gentamicin sulfate (5 mg/mL) and ethylenediaminetetraacetic acid disodium salt (EDTA-Na2, 30 mg/mL) could fully eradicate in vivo bacterial biofilms in totally implantable venous access ports (TIVAP). In this study, fabrication, conditioning and sterilization processes of...
Cytotoxic effect of Rosa canina extract on human colon cancer cells through repression of telomerase expression
Ibrahim Turan, Selim Demir, Kagan Kilinc, Serap Ozer Yaman, Sema Misir, Hanife Kara, Berna Genc, Ahmet Mentese, Yuksel Aliyazicioglu, Orhan Deger
2018, 8(6): 394-399.
Abstract(193) PDF(2) [Cited by] (47)
Abstract:
Rosa canina is a member of the genus Rosa that has long been used for medical objectives. Several studies have reported cytotoxic effects of different Rosa species, but there has been only limited investigation of the cytotoxic effect of R. canina. The purpose of the current study was to examine the...
Evaluation of naproxen-induced oxidative stress, hepatotoxicity and in-vivo genotoxicity in male Wistar rats
Mir Hilal Ahmad, Mahino Fatima, Mobarak Hossain, Amal Chandra Mondal
2018, 8(6): 400-406.
Abstract(151) PDF(3) [Cited by] (46)
Abstract:
Naproxen (NP), a nonsteroidal anti-inflammatory drug (NSAID), is used for the treatment of common pain, inflammation and tissue damage. Genotoxicity testing of NP is of prime importance as it represents the largest group of drugs to which humans are exposed. Not many genotoxic studies are reported o...
Recovery rates of combination antibiotic therapy using in vitro microdialysis simulating in vivo conditions
Jayesh A. Dhanani, Suzanne L. Parker, Jeffrey Lipman, Steven C. Wallis, Jeremy Cohen, John Fraser, Adrian Barnett, Michelle Chew, Jason A. Roberts
2018, 8(6): 407-412.
Abstract(127) PDF(6) [Cited by] (8)
Abstract:
Microdialysis is a technique used to measure the unbound antibiotic concentration in the interstitial spaces, the target site of action. In vitro recovery studies are essential to calibrating the microdialysis system for in vivo studies. The effect of a combination of antibiotics on recovery into mi...
Novel ligand-based docking; molecular dynamic simulations; and absorption, distribution, metabolism, and excretion approach to analyzing potential acetylcholinesterase inhibitors for Alzheimer's disease
Subramaniyan Vijayakumar, Palani Manogar, Srinivasan Prabhu, Ram Avadhar Sanjeevkumar Singh
2018, 8(6): 413-420.
Abstract(168) PDF(7) [Cited by] (53)
Abstract:
Acetylcholinesterase (AChE) plays an important role in Alzheimer's disease (AD). The excessive activity of AChE causes various neuronal problems, particularly dementia and neuronal cell deaths. Generally, anti- AChE drugs induce some serious neuronal side effects in humans. Therefore, this study sou...

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