2018 Vol. 8, No. 3

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2018, 8(3)
Abstract(50) PDF(0)
Abstract:
Overview of the detection methods for equilibrium dissociation constant KD of drug-receptor interaction
Weina Ma, Liu Yang, Langchong He
2018, 8(3): 147-152.
Abstract(201) PDF(16) [Cited by] (80)
Abstract:
Drug-receptor interaction plays an important role in a series of biological effects, such as cell pro-liferation, immune response, tumor metastasis, and drug delivery. Therefore, the research on drug-re-ceptor interaction is growing rapidly. The equilibrium dissociation constant (KD) is the basic pa...
Quantification and pharmacokinetic study of tumor-targeting agent MHI148-clorgyline amide in mouse plasma using liquid chromatography-electrospray ionization tandem mass spectrometry
Zhijun Wang, Bogdan Z. Olenyuk, Jean Chen Shih, Jeffrey Wang
2018, 8(3): 153-159.
Abstract(187) PDF(3) [Cited by] (5)
Abstract:
A high-performance liquid chromatography-electrospray ionization tandem mass spectrometric (HPLC-ESI-MS/MS) method was developed for the quantification of MHI148-clorgyline amide (NMI-amide), a novel tumor-targeting monoamine oxidase A inhibitor, in mouse plasma. The method was validated in terms of...
Simultaneous determination of acetaminophen and oxycodone in human plasma by LC–MS/MS and its application to a pharmacokinetic study
Wei Lu, Shunbo Zhao, Meng Gong, Luning Sun, Li Ding
2018, 8(3): 160-167.
Abstract(233) PDF(3) [Cited by] (26)
Abstract:
A simple and rapid liquid chromatography–tandem mass spectrometry (LC–MS/MS) method was de-veloped and validated for simultaneous determination of acetaminophen and oxycodone in human plasma. Acetaminophen-d4 and oxycodone-d3 were used as internal standards. The challenge en-countered in the method ...
Evaluation of physicochemical properties as supporting information on quality control of raw materials and veterinary pharmaceutical formulations
Sara da Silva Anacleto, Marcella Matos Cordeiro Borges, Hanna Leijoto de Oliveira, Andressa Reis Vicente, Eduardo Costa de Figueiredo, Marcone Augusto Leal de Oliveira, Bárbara Juliana Pinheiro Borges, Marcelo Antonio de Oliveira, Warley de Souza Borges, Keyller Bastos Borges
2018, 8(3): 168-175.
Abstract(97) PDF(0) [Cited by] (16)
Abstract:
This study aimed to show that the physicochemical proprieties obtained by Fourier transform infrared spectroscopy (FTIR), thermogravimetry (TG), and scanning electronic microscopy (SEM) can be useful tools for evaluating the quality of active pharmaceutical ingredients (APIs) and pharmaceutical prod...
Identification of three kinds of Plumeria flowers by DNA barcoding and HPLC specific chromatogram
Leilei Zhao, Xiaoxue Yu, Jie Shen, Xinjun Xu
2018, 8(3): 176-180.
Abstract(133) PDF(7) [Cited by] (10)
Abstract:
DNA barcoding and HPLC specific chromatogram were used to identify three kinds of Plumeria flowers respectively. DNAs extracted from the three Plumeria species were amplified by PCR with universal primers, and the psbA-trnH region was selected. All the amplified products were sequenced and the resul...
Enhancing the dissolution of phenylbutazone using Syloid? based mesoporous silicas for oral equine applications
Laura J. Waters, John P. Hanrahan, Joseph M. Tobin, Catherine V. Finch, Gareth M.B. Parkes, Shamsuddeen A. Ahmad, Faraj Mohammad, Maria Saleem
2018, 8(3): 181-186.
Abstract(105) PDF(1)
Abstract:
Three mesoporous silica excipients (Syloid? silicas AL-1 FP, XDP 3050 and XDP 3150) were formulated with a model drug known for its poor aqueous solubility, namely phenylbutazone, in an attempt to enhance the extent and rate of drug dissolution. Although other forms of mesoporous silica have been in...
Enrichment and immobilization of macromolecular analytes on a porous membrane utilizing permeation drag
Pedram Madadkar, Rahul Sadavarte, Raja Ghosh
2018, 8(3): 187-193.
Abstract(159) PDF(0)
Abstract:
Enrichment and immobilization of analytes by chemical bonding or physical adsorption is typically the first step in many commonly used analytical techniques. In this paper, we discuss a permeation drag based technique as an alternative approach for carrying out location-specific immobilization of ma...
Physics, chemistry, and Hirshfeld surface analyses of gamma-irradiated thalidomide to evaluate behavior under sterilization doses
Valner A.F.S.N. Mussel, Max P. Ferreira, Maria B.F. Marques, Maria I. Yoshida, Mariana R. Almeida, Bernardo L. Rodrigues, Wagner N. Mussel
2018, 8(3): 194-201.
Abstract(70) PDF(0) [Cited by] (5)
Abstract:
Thalidomide was indicated as a sedative and antiemetic and prescribed for pregnant women. Its tragic teratogenic effects culminated in withdrawal from the market. Since the discovery of its anti-angiogenic and anti-inflammatory actions, thalidomide has been used in the treatment of leprosy and multi...
Sensitive and rapid determination of amantadine without derivatization in human plasma by LC–MS/MS for a bioequivalence study
Abhaysingh Bhadoriya, Shivprakash Rathnam, Bhavesh Dasandi, Dharmesh Parmar, Mallika Sanyal, Pranav S. Shrivastav
2018, 8(3): 202-207.
Abstract(141) PDF(1) [Cited by] (13)
Abstract:
A highly sensitive, rapid and rugged liquid chromatography-tandem mass spectrometry (LC-ESI-MS/MS) method was developed for reliable estimation of amantadine (AMD), an antiviral drug in human plasma. The analyte and internal standard (IS), amantadine-d6 (AMD-d6), were extracted from 200 μL plasma by...

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