2015 Vol. 5, No. 5

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Application of analytical instruments in pharmaceutical analysis
2015, 5(5): Ⅰ-Ⅳ.
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LCMS-8050 Continuing the evolution of Shimadzu's UF technology, Shimadzu introduces the LCMS-8050 triple quadrupole mass spectrometer, offering unparalleled measurement speeds and high-sensitivity performance.
Species authentication and geographical origin discrimination of herbal medicines by near infrared spectroscopy:A review
Zhiguo Yu
2015, 5(5): 277-284. doi: 10.1016/j.jpha.2015.04.001
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Abstract:
Near infrared (NIR) spectroscopy as a rapid and nondestructive analytical technique, integrated with chemometrics, is a powerful process analytical tool for the pharmaceutical industry and is becoming an attractive complementary technique for herbal medicine analysis. This review mainly focuses on t...
Four new degradation products of doxorubicin:An application of forced degradation study and hyphenated chromatographic techniques
Dheeraj Kaushik, Gulshan Bansal
2015, 5(5): 285-295. doi: 10.1016/j.jpha.2015.05.003
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Forced degradation study on doxorubicin (DOX) was carried out under hydrolytic condition in acidic, alkaline and neutral media at varied temperatures, as well as under peroxide, thermal and photolytic conditions in accordance with International Conference on Harmonization (ICH) guidelines Q1(R2). It...
Multiple responses optimization in the development of a headspace gas chromatography method for the determination of residual solvents in pharmaceuticals
Carla M. Teglia, Milagros Montemurro, María M. De Zan, María S. Cámara
2015, 5(5): 296-306. doi: 10.1016/j.jpha.2015.02.004
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An efficient generic static headspace gas chromatography (HSGC) method was developed, optimized and validated for the routine determination of several residual solvents (RS) in drug substance, using a strategy with two sets of calibration. Dimethylsulfoxide (DMSO) was selected as the sample diluent ...
Application of RP-HPLC method in dissolution testing and statistical evaluation by NASSAM for simultaneous estimation of tertiary combined dosages forms
Yogesh Upadhyay, Nitin Sharma, G.S. Sarma, Ravindra K. Rawal
2015, 5(5): 307-315. doi: 10.1016/j.jpha.2014.11.001
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A dissolution method with robust high performance liquid chromatographic (HPLC) analysis for im-mediate release tablet formulation was developed and validated to meet the requirement as per Inter-national Conference on Harmonization (ICH) and United States Food and Drug Administration (USFDA) guidel...
High-sensitivity simultaneous liquid chromatography-tandem mass spectrometry assay of ethinyl estradiol and levonorgestrel in human plasma
Abhishek Gandhi, Swati Guttikar, Priti Trivedi
2015, 5(5): 316-326. doi: 10.1016/j.jpha.2015.02.002
Abstract(45) HTML Full Text PDF(0)
Abstract:
A sensitive and simultaneous liquid chromatography-tandem mass spectrometry method was developed and validated for quantification of ethinyl estradiol and levonorgestrel. The analytes were extracted with methyl-tert-butyl ether: n-hexane (50:50, v/v) solvent mixture, followed by dansyl derivatizatio...
Determination of atractylon in rat plasma by a GC-MS method and its application to a pharmacokinetic study
Han Yan, Yuanyuan Sun, Yuying Ma, Bin Ji, Xiaohong Hou, Zhiguo Yu, Yunli Zhao
2015, 5(5): 327-331. doi: 10.1016/j.jpha.2015.03.002
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A sensitive and selective method based on gas chromatography hyphenated to mass spectrometry (GC-MS) was developed and validated for the determination of atractylon in rat plasma. Plasma samples were processed by liquid-liquid extraction with ethyl acetate-n-hexane (1:1, v/v) using acetophenone as a...
Rapid screening and distribution of bioactive compounds in different parts of Berberis petiolaris using direct analysis in real time mass spectrometry
Awantika Singh, Vikas Bajpai, Mukesh Srivastava, Kamal Ram Arya, Brijesh Kumar
2015, 5(5): 332-335. doi: 10.1016/j.jpha.2015.05.002
Abstract(85) HTML Full Text PDF(1)
Abstract:
Berberis petiolaris Wall. ex G. Don, an unexplored medicinal plant belonging to the family Berberidaceae, is a large deciduous shrub found in Western Himalaya between 1800-3000 m. Chemical profiling of fruit, leaf, root and stem was done by direct analysis in real time mass spectrometry followed by ...

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