Journal of Pharmaceutical Analysis

2019, 9(2)

Abstract(135) PDF(4)

Abstract:
An international journal providing a forum for original and pertinent contributions in Pharmaceutical Analysis.

Methodology of drug screening and target identification for new necroptosis inhibitors

Pengchao Pan, Zhenyu Cai, Chunlin Zhuang, Xiaofei Chen, Yifeng Chai

2019, 9(2): 71-76.

Abstract(166) PDF(2) [Cited by] (13)

Abstract:
Apoptosis has been considered as the only form of regulated cell death for a long time. However, a novel form of programmed cell death called necroptosis was recently reported. The process of necroptosis is regulated and plays a critical role in the occurrence and development of multiple human disea...

Advancing USP compendial methods for fixed dose combinations: A case study of metoprolol tartrate and hydrochlorothiazide tablets

Qun Xu

2019, 9(2): 77-82.

Abstract(155) PDF(7) [Cited by] (8)

Abstract:
The current United States Pharmacopeia–National Formulary (USP–NF) includes more than 250 mono-graphs of fixed dose combinations (FDCs), and some of them need to be updated due to incompleteness of impurity profiles and obsolescence of analytical methodologies. A case study of metoprolol tartrate an...

Production and stability study of a hospital parenteral nutrition solution for neonates

Anne-Laure Yailian, Céline Serre, Justine Fayard, Marina Faucon, Patrick Thomaré, Samira Filali, Christine Pivot, Florence Vételé, Fabrice Pirot, Emmanuelle Olivier

2019, 9(2): 83-90.

Abstract(164) PDF(3) [Cited by] (13)

Abstract:
Standard parenteral nutrition solutions are mixtures comprising interacting components that may de-grade themselves over time. The objective of this study was to investigate the physicochemical and microbiological stability of a hospital preparation for parenteral nutrition in neonatology. The analy...

Identification of α-glucosidase inhibitors from Clinacanthus nutans leaf extract using liquid chromatography-mass spectrometry-based metabolomics and protein-ligand interaction with molecular docking

Suganya Murugesu, Zalikha Ibrahim, Qamar Uddin Ahmed, Bisha Fathamah Uzir, Nik Idris Nik Yusoff, Vikneswari Perumal, Faridah Abas, Khozirah Shaari, Alfi Khatib

2019, 9(2): 91-99.

Abstract(419) PDF(11) [Cited by] (41)

Abstract:
The present study used in vitro and in silico techniques, as well as the metabolomics approach to char-acterise α-glucosidase inhibitors from different fractions of Clinacanthus nutans. C. nutans is a medicinal plant belonging to the Acanthaceae family, and is traditionally used to treat diabetes in...

Development of a fast and precise method for simultaneous quantification of the PLGA monomers lactic and glycolic acid by HPLC

Marcel Pourasghar, Aljoscha Koenneke, Peter Meiers, Marc Schneider

2019, 9(2): 100-107.

Abstract(123) PDF(3) [Cited by] (22)

Abstract:
Poly(lactide-co-glycolide acid) (PLGA) is an extraordinary well-described polymer and has excellent pharmaceutical properties like high biocompatibility and good biodegradability. Hence, it is one of the most used materials for drug delivery and biomedical systems, also being present in several US F...

Controlled delivery of ibuprofen from poly(vinyl alcohol)-poly (ethylene glycol) interpenetrating polymeric network hydrogels

Subhraseema Das, Usharani Subuddhi

2019, 9(2): 108-116.

Abstract(106) PDF(3)

Abstract:
Hydrogels composed of poly(vinyl alcohol) (PVA) and poly(ethylene glycol) (PEG) were synthesized using glutaraldehyde as crosslinker and investigated for controlled delivery of the common anti-inflammatory drug, ibuprofen (IBF). To regulate the drug delivery, solid inclusion complexes (ICs) of IBF i...

Application of activated carbon-decorated polyacrylonitrile nanofibers as an adsorbent in dispersive solid-phase extraction of fluoroquinolones from wastewater

K. Mogolodi Dimpe, Philiswa N. Nomngongo

2019, 9(2): 117-126.

Abstract(131) PDF(3) [Cited by] (48)

Abstract:
A cheap and simple sample preparation method, consisting of a dispersive solid-phase method and an ad-sorbent, activated carbon decorated PAN nanofibers, was employed and used for the extraction of antibiotics (ciprofloxacin, danofloxacin, and enrofloxacin) in wastewater. Electrospun PAN nanofibers ...

Development of nitrogen and sulfur-doped carbon dots for cellular imaging

Hui Liu, Yue Zhang, Chengzhi Huang

2019, 9(2): 127-132.

Abstract(109) PDF(7) [Cited by] (50)

Abstract:
Heteroatom-doped carbon dots (CDs) have attracted extensive interest because of their improved elec-tronic and fluorescence properties with heteroatom doping. In this study, a new synthetic method for nitrogen (N) and sulfur (S) -doped CDs was developed via a hydrothermal method using methionine and...

Pharmacokinetic evaluation, molecular docking and in vitro biological evaluation of 1, 3, 4-oxadiazole derivatives as potent antioxidants and STAT3 inhibitors

Rashmin khanam, Iram I. Hejazi, Syed Shahabuddin, Abdul R. Bhat, Fareeda Athar

2019, 9(2): 133-141.

Abstract(184) PDF(2) [Cited by] (21)

Abstract:
1, 3, 4-Oxadiazole derivatives (4a–5f) were previously synthesized to investigate their anticancer properties. However, studies relating to their antioxidant potential and signal transducer and activator of transcription (STAT) inhibition have not been performed. We investigated previously synthesiz...

2019 Vol. 9, No. 2