2017 Vol. 7, No. 6

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Journal of Pharmaceutical Analysis
2017, 7(6): 后插1-2.
Abstract(92) PDF(0)
Abstract:
Application of HPLC and ESI-MS techniques in the analysis of phenolic acids and flavonoids from green leafy vegetables (GLVs)
Ramesh Kumar Bonta
2017, 7(6): 349-364.
Abstract(199) PDF(9)
Abstract:
Diets containing high proportions of fruits and vegetables reduce the risk of onset of chronic diseases.The role of herbal medicines in improving human health is gaining popularity over the years,which also increases the need for safety and efficiency of these products.Green leafy vegetables(GLVs)ar...
Development of a novel stability indicating RP-HPLC method for quantification of Connexin43 mimetic peptide and determination of its degradation kinetics in biological fluids
Rohit Bisht, Ilva D. Rupenthal, Sreevalsan Sreebhavan, Jagdish K. Jaiswal
2017, 7(6): 365-373.
Abstract(73) PDF(0)
Abstract:
Connexin43 mimetic peptide (Cx43MP) has been intensively investigated for its therapeutic effect in the management of inflammatory eye conditions, spinal cord injury, wound healing and ischemia-induced brain damage. Here, we report on a validated stability–indicating reversed-phase high performance ...
A validated UPLC–MS/MS method for simultaneous determination of imatinib,dasatinib and nilotinib in human plasma
Jing Zeng, Hualin Cai, Zhiping Jiang, Qing Wang, Yan Zhu, Ping Xu, Xielan Zhao
2017, 7(6): 374-380.
Abstract(128) PDF(1)
Abstract:
A sensitive, rapid, simple and economical ultra-performance liquid chromatography–tandem mass spectro-metric method (UPLC–MS/MS) was developed and validated for simultaneous determination of imatinib, dasatinib and nilotinib in human plasma using gliquidone as internal standard (IS). Liquid-liquid e...
Development and validation of a high throughput LC–MS/MS method for simultaneous quantitation of pioglitazone and telmisartan in rat plasma and its application to a pharmacokinetic study
Pinaki Sengupta, Bappaditya Chatterjee, Uttam Kumar Mandal, Bapi Gorain, Tapan Kumar Pal
2017, 7(6): 381-387.
Abstract(291) PDF(10)
Abstract:
Management of cardiovascular risk factors in diabetes demands special attention due to their co-existence. Pioglitazone (PIO) and telmisartan (TLM) combination can be beneficial in effective control of cardiovascular complication in diabetes.In this research,we developed and validated a high through...
Application of a validated HPLC-PDA method for the determination of melatonin content and its release from poly(lactic acid)nanoparticles
Leiziani Gnatkowski Martins, Najeh Maissar Khalil, Rubiana Mara Mainardes
2017, 7(6): 388-393.
Abstract(304) PDF(8)
Abstract:
Melatonin is a natural hormone and with the advancement of age its production declines and thereby may result in some neurological disorders.Exogenous administration of melatonin has been suggested as a neuroprotective agent. Due to its low oral bioavailability, the loading of melatonin in polymeric...
Synthesis,isolation,identification and characterization of new process-related impurity in isoproterenol hydrochloride by HPLC,LC/ESI-MS and NMR
Neeraj Kumar, Subba Rao Devineni, Prasad Reddy Gajjala, Shailendra Kumar Dubey, Pramod Kumar
2017, 7(6): 394-400.
Abstract(205) PDF(15)
Abstract:
One unknown impurity(Imp-II)during the analysis of laboratory batches of isoproterenol hydrochloride was detected in the level ranging from 0.04% to 0.12% by high performance liquid chromatography with UV detection. The unknown impurity structure was proposed as 4-[2-(propan-2-ylamino)ethyl]benzene-...
Quantification of theophylline or paracetamol in milk matrices by high-performance liquid chromatography
Tania A.P. Fernandes, Jo?o P. Aguiar, Ana I. Fernandes, Jo?o F. Pinto
2017, 7(6): 401-405.
Abstract(98) PDF(1)
Abstract:
A simple, accurate and sensitive high-performance liquid chromatography (HPLC) method was developed, validated and applied to the determination of either theophylline or paracetamol in milk-based samples. The method allowed drug quantification in fresh and powdered milk with a relatively short run t...
Development of a UPLC–MS/MS method for determination of pimavanserin tartrate in rat plasma:Application to a pharmacokinetic study
Shixiao Wang, Yang Wang, Shuang Gao, Yuanyuan Zhang, Hanpei Wang, Longshan Zhao, Kaishun Bi, Shaojie Wang, Xiaohui Chen
2017, 7(6): 406-410.
Abstract(69) PDF(0)
Abstract:
A simple, rapid and sensitive method based on an ultra-performance liquid chromatography–tandem mass spectrometry(UPLC–MS/MS)has been developed and validated for the determination of pimavanserin in rat plasma.The analyte was extracted by protein precipitation with methanol and separated on an ACQUI...
Simultaneous colorimetric determination of morphine and ibuprofen based on the aggregation of gold nanoparticles using partial least square
Morteza Bahram, Tayyebeh Madrakian, Sakineh Alizadeh
2017, 7(6): 411-416.
Abstract(191) PDF(5)
Abstract:
In this work a new method is presented for simultaneous colorimetric determination of morphine(MOR)and ibuprofen(IBU)based on the aggregation of citrate-capped gold nanoparticles(AuNPs).Citrate-capped AuNPs were aggregated in the presence of MOR and IBU. The difference in kinetics of AuNPs aggregati...
Determination of ergocalciferol in human plasma after Diels-Alder derivatization by LC–MS/MS and its application to a bioequivalence study
Pritesh Contractor, Abhishek Gandhi, Gajendra Solanki, Priyanka A. Shah, Pranav S. Shrivastav
2017, 7(6): 417-422.
Abstract(77) PDF(1)
Abstract:
An accurate, sensitive and selective method is developed for determination of ergocalciferol (vitamin D2) in human plasma using LC–MS/MS.After liquid-liquid extraction with n-hexane,ergocalciferol was derivatized by reacting with 4-phenyl-1,2,4-triazoline-3,5-dione (PTAD), a strong dienophile based ...

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