2016 Vol. 6, No. 3

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Analytical methods for determination of terbinafine hydrochloride in pharmaceuticals and biological materials$
Basavaiah Kanakapura n, Vamsi Krishna Penmatsa
2016, 6(3): 137-149.
Abstract(142) PDF(5)
Abstract:
Terbinafine is a new powerful antifungal agent indicated for both oral and topical treatment of myco-sessince. It is highly effective in the treatment of determatomycoses. The chemical and pharmaceutical analysis of the drug requires effective analytical methods for quality control and pharmacodynam...
Ion-pairing HPLC methods to determine EDTA and DTPA in small molecule and biological pharmaceutical formulations$
George Wang, Frank P. Tomasella
2016, 6(3): 150-156.
Abstract(156) PDF(7)
Abstract:
Ion-pairing high-performance liquid chromatography–ultraviolet (HPLC–UV) methods were developed to determine two commonly used chelating agents, ethylenediaminetetraacetic acid (EDTA) in Abilifys (a small molecule drug with aripiprazole as the active pharmaceutical ingredient) oral solution and die-...
A novel surface molecularly imprinted polymer as the solid-phase extraction adsorbent for the selective determination of ampicillin sodium in milk and blood samples$
Ningli Wu, Zhimin Luo, Yanhui Ge, Pengqi Guo, Kangli Du, Weili Tang, Wei Du, Aiguo Zeng, Chun Chang, Qiang Fu
2016, 6(3): 157-164.
Abstract(147) PDF(6)
Abstract:
Surface molecularly imprinted polymers (SMIPs) for selective adsorption of ampicillin sodium were synthesized using surface molecular imprinting technique with silica gel as a support. The physical and morphological characteristics of the polymers were investigated by scanning electron microscope (S...
Molecular dynamics of amorphous pharmaceutical fenofibrate studied by broadband dielectric spectroscopy$
U. Sailaja, M. Shahin Thayyil, N.S. Krishna Kumar, G. Govindaraj
2016, 6(3): 165-170.
Abstract(161) PDF(5)
Abstract:
Fenofibrate is mainly used to reduce cholesterol level in patients at risk of cardiovascular disease. Thermal transition study with the help of differential scanning calorimetry (DSC) shows that the aforesaid active pharmaceutical ingredient (API) is a good glass former. Based on our DSC study, the ...
On-line near-infrared spectroscopy optimizing and monitoring biotransformation process ofγ-aminobutyric acid$
Guoyu Ding, Yuanyuan Hou, Jiamin Peng, Yunbing Shen, Min Jiang, Gang Bai
2016, 6(3): 171-178.
Abstract(98) PDF(4)
Abstract:
Near-infrared spectroscopy (NIRS) with its fast and nondestructive advantages can be qualified for the real-time quantitative analysis. This paper demonstrates that NIRS combined with partial least squares (PLS) regression can be used as a rapid analytical method to simultaneously quantify L-glutami...
Monitoring real time polymorphic transformation of sulfanilamide by diffuse reflectance visible spectroscopy$
Tracy O. Ehiwe, Bruce D. Alexander, John C. Mitchell, Martin J. Snowden, Laura J. Waters
2016, 6(3): 179-183.
Abstract(98) PDF(2)
Abstract:
This study investigated the development of a novel approach to surface characterization of drug poly-morphism and the extension of the capabilities of this method to perform ‘real time’ in situ measure-ments. This was achieved using diffuse reflectance visible (DRV) spectroscopy and dye deposition, ...
Development of an LC-MS/MS method for the quantitation of deoxyglycychloxazol in rat plasma and its application in pharmacokinetic study$
Rongshan Li, Ruixue Ran, Quansheng Li, Yurong Huang, Yuan Gu, Duanyun Si
2016, 6(3): 184-189.
Abstract(186) PDF(2)
Abstract:
Deoxyglycychloxazol (TY501) is a glycyrrhetinic acid derivative which exhibits high anti-inflammatory activity and reduced pseudoaldosteronism compared to glycyrrhetinic acid. In this study, a sensitive and rapid liquid chromatography–tandem mass spectrometry (LC–MS/MS) method was established for th...
Development and validation of a high throughput UPLC-MS/MS method for simultaneous quantification of esomeprazole, rabeprazole and levosulpiride in human plasma$
Raja Haranadha Babu Chunduri a, n, Gowri Sankar Dannana b
2016, 6(3): 190-198.
Abstract(160) PDF(18)
Abstract:
A high throughput ultra pressure liquid chromatography–mass spectrometry (UPLC–MS/MS) method with good sensitivity and selectivity has been developed and validated for simultaneous quantification of esomeprazole, rabeprazole and levosulpiride in human plasma using lansoprazole as internal standard (...
Simultaneous determination of doxorubicin and its dipeptide prodrug in mice plasma by HPLC with fluorescence detection$
Jing Han, Jue Zhang, Haiyan Zhao, Yan Li, Zilin Chen
2016, 6(3): 199-202.
Abstract(124) PDF(3)
Abstract:
A simple and sensitive high performance liquid chromatography with fluorescence detection (HPLC–FD) has been developed for simultaneous quantification of doxorubicin (DOX) and its dipeptide conjugate prodrug (PDOX) in mice plasma. The chromatographic separation was carried out on an Amethyst C18–H c...
Preliminary assessment of two non-destructive instrumental techniques for quality evaluation of Lobelia chinensis Lour.$
Hong-Peng Chen, Wen-Jia Pan, Nan Tang, Yuan Zhang, Mei-Ling Yu, Xing-Da Wu
2016, 6(3): 203-206.
Abstract(82) PDF(2)
Abstract:
Two non-destructive instrumental methods, infrared spectroscopy (IR) and X-ray diffraction (XRD), were studied for quality evaluation of Lobelia chinensis Lour. (L. chinensis). We obtained the IR spectra and XRD patterns of L. chinensis collected from different sources. The similarity of samples was...

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