Journal of Pharmaceutical Analysis

JPA Prize in 2014

2015, 5(4)

Abstract(96) PDF(2)

Abstract:

Application of analytical instruments in pharmaceutical analysis

2015, 5(4): Ⅰ-Ⅳ.

Abstract(138) PDF(2)

Abstract:

Quantitative bioanalytical and analytical method development of dibenzazepine derivative, carbamazepine: A review☆

Prasanna A. Datar

2015, 5(4): 213-222. doi: 10.1016/j.jpha.2015.02.005

Abstract(60) HTML Full Text PDF(3)

Abstract:
Bioanalytical methods are widely used for quantitative estimation of drugs and their metabolites in physiological matrices. These methods could be applied to studies in areas of human clinical pharma-cology and toxicology. The major bioanalytical services are method development, method validation an...

Development and validation of a GC-FID method for quantitative analysis of oleic acid and related fatty acids☆

Honggen Zhang, Zhenyu Wang, Oscar Liu

2015, 5(4): 223-230. doi: 10.1016/j.jpha.2015.01.005

Abstract(168) HTML Full Text PDF(4)

Abstract:
Oleic acid is a common pharmaceutical excipient that has been widely used in various dosage forms. Gas chromatography (GC) has often been used as the quantitation method for fatty acids normally requiring a derivatization step. The aim of this study was to develop a simple, robust, and derivatizatio...

Fabrication of multiwalled carbon nanotube-surfactant modified sensor for the direct determination of toxic drug 4-aminoantipyrine☆

Jayant I. Gowda, Arunkumar T. Buddanavar, Sharanappa T. Nandibewoor

2015, 5(4): 231-238. doi: 10.1016/j.jpha.2015.01.001

Abstract(120) HTML Full Text PDF(2)

Abstract:
A multi-walled carbon nanotube (MWCNT)-cetyltrimethylammonium bromide (CTAB) surfactant composite modified glassy carbon electrode (GCE) was developed as a novel system for the determination of 4-aminoantipyrine(AAP). The oxidation process was irreversible over the pH range studied and exhibited a d...

Simultaneous determination of four Sudan dyes in rat blood by UFLC-MS/MS and its application to a pharmacokinetic study in rats☆

Hao Zhu, Yijun Chen, Changshun Huanga, Yangyang Han, Yiwei Zhang, Shucan Xie

2015, 5(4): 239-248. doi: 10.1016/j.jpha.2015.03.001

Abstract(153) HTML Full Text PDF(2)

Abstract:
A rapid and sensitive method based on ultrafast liquid chromatography-tandem mass spectrometry was developed and validated for simultaneous determination of Sudan Ⅰ, Sudan Ⅱ, Sudan Ⅲ, and Sudan Ⅳ levels in rat whole blood. Cleanert C18 mixed-mode polymeric sorbent was used for effective solid-phase ...

Multi-spectroscopic investigation of the binding interaction of fosfomycin with bovine serum albumin☆

Manjunath D. Meti, Sharanappa T. Nandibewoor, Shrinivas D. Joshi, Uttam A. More, Shivamurti A. Chimatadar

2015, 5(4): 249-255. doi: 10.1016/j.jpha.2015.01.004

Abstract(101) HTML Full Text PDF(1)

Abstract:
The interaction between fosfomycin (FOS) and bovine serum albumin (BSA) has been investigated effectively by multi-spectroscopic techniques under physiological pH 7.4. FOS quenched the intrinsic fluorescence of BSA via static quenching. The number of binding sites n and observed binding constant KA ...

Identification, synthesis and characterization of process related impurities of benidipine hydrochloride, stress-testing/stability studies and HPLC/UPLC method validations☆

Esen Bellur Atici, Bekir Karli?a

2015, 5(4): 256-268. doi: 10.1016/j.jpha.2015.02.001

Abstract(272) HTML Full Text PDF(6)

Abstract:
Benidipine hydrochloride, used as an antihypertensive agent and long-acting calcium antagonist, is synthesized for commercial use as a drug substance in highly pure form. During the synthetic process development studies of benidipine, process related impurities were detected. These impurities were i...

Simultaneous quantitation of folic acid and 5-methyltetrahydrofolic acid in human plasma by HPLC-MS/MS and its application to a pharmacokinetic study☆

Xiao-Hong Zheng, Li-Yuan Jiang, Lan-Ting Zhao, Quan-Ying Zhang, Li Ding

2015, 5(4): 269-275. doi: 10.1016/j.jpha.2015.05.004

Abstract(119) HTML Full Text PDF(0)

Abstract:
A sensitive method based on high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been developed for the simultaneous determination of folic acid (FA) and its active metabolite, 5-methyltetrahydrofolic acid (5-M-THF), in human plasma. The analytes were extracted from plasma ...

2015 Vol. 5, No. 4