Hypothalamic lipidomics reveals that AMPK-FA metabolism mediates the energy-balancing effect of the four typical “hot” herbs on hypothyroidism

Yangyang Wang; Yizhou Rong; Liangce Chen; Qi Cui; Haixue Kuang; Bo Yang

doi:10.1016/j.jpha.2024.101151

Volume 15 Issue 4

May 2025

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Yangyang Wang, Yizhou Rong, Liangce Chen, Qi Cui, Haixue Kuang, Bo Yang. Hypothalamic lipidomics reveals that AMPK-FA metabolism mediates the energy-balancing effect of the four typical “hot” herbs on hypothyroidism[J]. Journal of Pharmaceutical Analysis, 2025, 15(4): 101151. doi: 10.1016/j.jpha.2024.101151

Citation:

Yangyang Wang, Yizhou Rong, Liangce Chen, Qi Cui, Haixue Kuang, Bo Yang. Hypothalamic lipidomics reveals that AMPK-FA metabolism mediates the energy-balancing effect of the four typical “hot” herbs on hypothyroidism[J]. Journal of Pharmaceutical Analysis, 2025, 15(4): 101151. doi: 10.1016/j.jpha.2024.101151

Citation:

Yangyang Wang, Yizhou Rong, Liangce Chen, Qi Cui, Haixue Kuang, Bo Yang. Hypothalamic lipidomics reveals that AMPK-FA metabolism mediates the energy-balancing effect of the four typical “hot” herbs on hypothyroidism[J]. Journal of Pharmaceutical Analysis, 2025, 15(4): 101151. doi: 10.1016/j.jpha.2024.101151

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Hypothalamic lipidomics reveals that AMPK-FA metabolism mediates the energy-balancing effect of the four typical “hot” herbs on hypothyroidism

doi: 10.1016/j.jpha.2024.101151

a. School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 311402, China;
b. Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin, 150040, China

Funds:

This research was supported by the Chief Scientist of Qi-Huang Project of the National Traditional Chinese Medicine Inheritance and Innovation “One Hundred Million” Talent Project, China (Grant No.: [2021] No. 7), the National Famous Old Traditional Chinese Medicine Experts Inheritance Studio Construction Program of National Administration of Traditional Chinese Medicine, China (Grant No.: [2022] No. 75), the Seventh Batch of National Famous Old Traditional Chinese Medicine Experts Experience Heritage Construction Program of National Administration of Traditional Chinese Medicine, China (Grant No.: [2022] No. 76), Heilongjiang Touyan Innovation Team Program, China (Grant No.: [2019] No. 5), the Natural Science Foundation of Zhejiang Province (Grant No.: LQN25H280009), and the Research Project of Zhejiang Chinese Medical University, China (Grant No.: 2023RCZXZK22).

Received Date: Aug. 23, 2024
Accepted Date: Nov. 18, 2024
Rev Recd Date: Nov. 01, 2024
Publish Date: Nov. 20, 2024

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References

[1]	M. Lopez, L. Varela, M.J. Vazquez, et al., Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance, Nat. Med. 16 (2010) 1001-1008.
[2]	Y.-Y. Wang, Y.-P. Sun, B.-Y. Yang, et al., Application of metabolomics and network analysis to reveal the ameliorating effect of four typical “hot” property herbs on hypothyroidism rats, Front. Pharmacol. 13 (2022), 955905.