Open flow microperfusion to assess local drug concentrations in the buccal mucosa

Laura Wiltschko; Paula Fischer; Simon Schwingenschuh; Reingard Raml; Georg Raber; Thomas Birngruber; Eva Roblegg

doi:10.1016/j.jpha.2024.101135

Volume 15 Issue 4

May 2025

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Laura Wiltschko, Paula Fischer, Simon Schwingenschuh, Reingard Raml, Georg Raber, Thomas Birngruber, Eva Roblegg. Open flow microperfusion to assess local drug concentrations in the buccal mucosa[J]. Journal of Pharmaceutical Analysis, 2025, 15(4): 101135. doi: 10.1016/j.jpha.2024.101135

Citation:

Laura Wiltschko, Paula Fischer, Simon Schwingenschuh, Reingard Raml, Georg Raber, Thomas Birngruber, Eva Roblegg. Open flow microperfusion to assess local drug concentrations in the buccal mucosa[J]. Journal of Pharmaceutical Analysis, 2025, 15(4): 101135. doi: 10.1016/j.jpha.2024.101135

Citation:

Laura Wiltschko, Paula Fischer, Simon Schwingenschuh, Reingard Raml, Georg Raber, Thomas Birngruber, Eva Roblegg. Open flow microperfusion to assess local drug concentrations in the buccal mucosa[J]. Journal of Pharmaceutical Analysis, 2025, 15(4): 101135. doi: 10.1016/j.jpha.2024.101135

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Open flow microperfusion to assess local drug concentrations in the buccal mucosa

doi: 10.1016/j.jpha.2024.101135

a. HEALTH-Institute for Biomedical Research and Technologies, Joanneum Research Forschungsgesellschaft mbH, Graz, 8010, Austria;
b. Institute of Pharmaceutical Sciences, Pharmaceutical Technology and Biopharmacy, University of Graz, Graz, 8010, Austria;
c. Institute of Analytical Chemistry, University of Graz, Graz, 8010, Austria

Received Date: Jul. 12, 2024
Accepted Date: Oct. 29, 2024
Rev Recd Date: Oct. 07, 2024
Publish Date: Oct. 31, 2024

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References(5)

References

[1]	S. Wang, A. Zuo, J. Guo, Types and evaluation of in vitro penetration models for buccal mucosal delivery, J. Drug Deliv. Sci. Technol. 61 (2021), 102122.
[2]	C.A. Lesch, C.A. Squier, A. Cruchley, et al., The permeability of human oral mucosa and skin to water, J. Dent. Res. 68 (1989) 1345-1349.
[3]	V.F. Patel, F. Liu, M.B. Brown, Modeling the oral cavity: In vitro and in vivo evaluations of buccal drug delivery systems, J. Control. Release 161 (2012) 746-756.
[4]	M. Bodenlenz, K.I. Tiffner, R. Raml, et al., Open flow microperfusion as a dermal pharmacokinetic approach to evaluate topical bioequivalence, Clin. Pharmacokinet. 56 (2017) 91-98.
[5]	L. Wiltschko, E. Roblegg, R. Raml, et al., Small volume rapid equilibrium dialysis (RED) measures effects of interstitial parameters on the protein-bound fraction of topical drugs, J. Pharm. Biomed. Anal. 234 (2023), 115571.