Single-cell RNA sequencing reveals the changes of the pulmonary immune environment in rat after <i>Siegesbeckia orientalis</i> L. treatment

Fan Zhang; Shu Gan; Jingjing Liao; Ting Jiang; Zhiqiang Shi; Xueying Fan; Hiu-Yee Kwan; Zhongqiu Liu; Tao Su

doi:10.1016/j.jpha.2024.101035

Volume 14 Issue 11

Nov. 2024

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Fan Zhang, Shu Gan, Jingjing Liao, Ting Jiang, Zhiqiang Shi, Xueying Fan, Hiu-Yee Kwan, Zhongqiu Liu, Tao Su. Single-cell RNA sequencing reveals the changes of the pulmonary immune environment in rat after Siegesbeckia orientalis L. treatment[J]. Journal of Pharmaceutical Analysis, 2024, 14(11): 101035. doi: 10.1016/j.jpha.2024.101035

Citation:

Fan Zhang, Shu Gan, Jingjing Liao, Ting Jiang, Zhiqiang Shi, Xueying Fan, Hiu-Yee Kwan, Zhongqiu Liu, Tao Su. Single-cell RNA sequencing reveals the changes of the pulmonary immune environment in rat after Siegesbeckia orientalis L. treatment[J]. Journal of Pharmaceutical Analysis, 2024, 14(11): 101035. doi: 10.1016/j.jpha.2024.101035

Citation:

Fan Zhang, Shu Gan, Jingjing Liao, Ting Jiang, Zhiqiang Shi, Xueying Fan, Hiu-Yee Kwan, Zhongqiu Liu, Tao Su. Single-cell RNA sequencing reveals the changes of the pulmonary immune environment in rat after Siegesbeckia orientalis L. treatment[J]. Journal of Pharmaceutical Analysis, 2024, 14(11): 101035. doi: 10.1016/j.jpha.2024.101035

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Single-cell RNA sequencing reveals the changes of the pulmonary immune environment in rat after Siegesbeckia orientalis L. treatment

doi: 10.1016/j.jpha.2024.101035

Fan Zhang^a,
Shu Gan^b,
Jingjing Liao^a,
Ting Jiang^a,
Zhiqiang Shi^a,
Xueying Fan^a,
Hiu-Yee Kwan^{c
,
,},
Zhongqiu Liu^{a,d
,
,},
Tao Su^{a
,
,}

a. State Key Laboratory of Traditional Chinese Medicine Syndrome, International Institute for Translational Chinese Medicine, School of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China;
b. The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510120, China;
c. Centre for Cancer & Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, 999077, China;
d. State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macao SAR, 999078, China

Funds:

This work was supported by the National Key Research and Development Program of China (Grant No.: 2023YFC3502800), the National Natural Science Foundation of China (Grant Nos.: 82274158 and 82074019), the Characteristic Innovation Projects of Universities in Guangdong Province, China (Grant No.: 2023KTSCX023), the Administration of Traditional Chinese Medicine of Guangdong Province, China (Grant Nos.: 20222042 and 20241074), the Young Elite Scientists Sponsorship Program by China Association of Chinese Medicine (Grant No.: 2021-QNRC2-B15), Guangdong Basic and Applied Basic Research Foundation, China (Grant No.: 2020B1515130005), the Special Research Project of Traditional Chinese Medicine Science and Technology of Guangdong Provincial Hospital of Traditional Chinese Medicine, China (Grant No.: YN2020MS04), and the Special Program for Top Talents of Guangdong Provincial Hospital of Traditional Chinese Medicine, China (Grant No.: BJ2022YL03).

Received Date: Mar. 19, 2024
Accepted Date: Jul. 01, 2024
Rev Recd Date: Jun. 27, 2024
Publish Date: Jul. 02, 2024

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References(5)

References

[1]	T. Jiang, L. Liu, M. Zhang, et al., Metabolomics reveals the mechanisms for the pulmonary toxicity of Siegesbeckia orientalis L. and the toxicity-reducing effect of processing, Front. Pharmacol. 12 (2021), 630319.
[2]	B. Van de Sande, C. Flerin, K. Davie, et al., A scalable SCENIC workflow for single-cell gene regulatory network analysis, Nat. Protoc. 15 (2020) 2247-2276.
[3]	S. Jin, C.F. Guerrero-Juarez, L. Zhang, et al., Inference and analysis of cell-cell communication using CellChat, Nat. Commun. 12 (2021), 1088.
[4]	C. Shi, E.G. Pamer, Monocyte recruitment during infection and inflammation, Nat. Rev. Immunol. 11 (2011) 762-774.
[5]	C.K. Lin, T.H. Huang, C. Yang, et al., Roles of lung-recruited monocytes and pulmonary vascular endothelial growth factor (VEGF) in resolving ventilator-induced lung injury (VILI), PLoS One 16 (2021), e0248959.